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Department of Infectious Diseases

Eric T. Harvill

Eric T. Harvill

PhD
University of Georgia Athletic Association Professor of Medical Microbiology
Email: .(JavaScript must be enabled to view this email address)
CVI room 1562


Educational Background

 PhD (1996), Immunology, University of California at Los Angeles


About Eric T. Harvill

Eric T. Harvill completed his PhD in Immunology at UCLA in 1996 and postdoctoral studies in Microbial Pathogenesis.  He has served the National Academies, NIH, USDA, DOD and other agencies in a variety of capacities and has served on many review panels and editorial boards.  He advanced to Distinguished Professor of Microbiology and Infectious Disease at Penn State and in 2016 is transitioning to the Department of Infectious Diseases in the College of Veterinary Medicine at the University of Georgia.  He holds the honorary title of Visiting Professor in the Singapore Centre on Environmental Life Sciences Engineering (SCELSE) at Lee Kong Chian Medicine and Nanyang Technological University.  He has published over 100 peer-reviewed articles in a wide variety of journals.


Research Interests

Although respiratory pathogens are a leading cause of death worldwide, we know very little about how invading bacterial pathogens overcome resident microbiota to colonize a host. Recently, we observed displacement of both culturable and unculturable bacteria from the upper respiratory tract upon infection with a common murine respiratory pathogen, Bordetella bronchiseptica. We examine the mechanistic basis for B. bronchiseptica displacement of other respiratory microbiota during infection. In parallel, we have demonstrated that resident microorganisms can prevent B. pertussis colonization and influence (apparent) host specificity. These results reveal an experimental system in which we can study how resident bacteria prevent pathogen invasion, and, provide rationale for manipulating microbiomes to protect the host and to create more accurate animal models of infectious diseases. Our approach has revealed complex intra-host competition between invading pathogen and resident microbiota and demonstrate novel effects of bacterial secretion systems and host immune functions in this in vivo competition. They also provide a striking example of displacement of chronic colonizers of the mammalian respiratory tract, potentially revealing novel pathways to disrupt the carrier state of a variety of common opportunistic respiratory pathogens.


Selected Publications

Search PubMed for harvill et

  • Linz B, Ivanov YV, Preston A, Brinkac L, Parkhill J, Kim M, Harris SR,Goodfield LL, Fry NK, Gorringe AR, Nicholson TL, Register KB, Losada L, Harvill ET. Acquisition and loss of virulence-associated factors during genome evolution and speciation in three clades of Bordetella species. BMC Genomics. 2016
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