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Department of Infectious Diseases

Mark W. Jackwood

BS, MS, PhD
Department Head, Poultry Diagnostic and Research Center
The J.R. Glisson Professor of Avian Medicine


Educational Background

BS (1978) Animal Science, University of Delaware, Animal Science
MS (1982) Virology, University of Delaware
PhD (1985) Microbiology, The Ohio State University


Research Interests

Dr. Jackwood is a molecular virologist. His primary area of research is the study of avian coronaviruses. Specifically, he works with infectious bronchitis virus (IBV), a coronavirus that causes an upper-respiratory disease in chickens, and turkey coronavirus (TCoV), an enteric disease in turkeys, which is also associated with poult enteritis mortality syndrome (PEMS). Dr. Jackwood’s work involves the use of molecular techniques for the identification, characterization, and control of these viruses.


Awards

The 2014 Charles Beard Research Excellence Award (U.S. Poultry & Egg Foundation)


Selected Publications

Jackwood, M. W. , D. L. Suarez, D. Hilt, M. J. Pantin-Jackwood, E. Spackman, P. Woolcock, and C. Cardona. Biological Characterization of Chicken-Derived H6N2 Low Pathogenic Avian Influenza Viruses in Chickens and Ducks. Avian Dis. Avian Dis. 54:120-125, 2010.

Jackwood, M. W. , T. O. Boynton, D. A. Hilt, E. T. McKinley, J. C. Kissinger, A. H. Paterson, J. Robertson, c. Lemke, A. W. McCall, S. M. Williams, J. W. Jackwood, and L. A. Byrd. Emergence of a Group 3 Coronavirus Through Recombination. Virology, 398:98-108. 2010.

Jackwood, M. W. , R. Rosenbloom, M. Petteruti, D. A. Hilt, A. W. McCall, and S. M. Williams. Avian Coronavirus Infectious Bronchitis Virus Susceptibility to Botanical Oleoresins and Essential Oils In Vitro and In Vivo. Virus Research, 149:86-94. 2010.

Jackwood, M. W. , D. A. Hilt, H. S. Sellers, S. M. Williams, and H. N. Lasher. Rapid Heat-Treatment Attenuation of Infectious Bronchitis Virus. Avian Pathology 39:227-233, 2010.

Panshin, A., N. Golender, I. Davidson, S. Nagar, M. Garcia, Jackwood, M. W. , E. Mundt, A. Alturi, S. Perk. Variavility of NS1 proteins among H9N2 avian influenza viruses isolated in Israel during 2000-2009. Virus Genes 41:396-405, 2010.

McKinley, E. T., Jackwood, M. W. , D. A. Hilt, J. C. Kissinger, J. S. Robertson, C. Lemke, and A. H. Paterson. Attenuated live vaccine usage affects accurate measures of virus diversity and mutation rates in avian coronavirus infectious bronchitis virus. Virus Research. 158:225-234, 2011.

Franca, M., P. R. Woolcock, M. Yu, Jackwood, M. W. and H. L. Shivaprasad. Nephritis associated with infectious bronchitis virus Cal99 variant in game chickens. Avian Dis. 55:422-428, 2011.

Keeler, S. P., P. J. Ferro, J. D. Brown, X. Fang, J. El-Attrache, R. Poulson, Jackwood, M. W. and D. E. Stallknecht. Use Of FTA® Sampling Cards For Molecular Detection Of Avian Influenza Virus in Wild Birds. Avian Dis. 56:200-207, 2012.

Phillips, J. E., Jackwood, M. W. , E. T. McKinley, S. W. Thor, D. A. Hilt, N. D. Acevedol, S. M. Williams, J. C. Kissinger, A. H Paterson, J. S. Robertson, C. Lemke. Changes in nonstructural protein 3 are associated with attenuation in avian coronavirus infectious bronchitis virus. Virus Genes 44:63-74, 2012.

Thor, S. W., D. A. Hilt, J. C. Kissinger, A. H. Paterson, and Jackwood, M. W. , Recombination in Avian Gamma-Coronaviruses. Viruses. 3:1777-1799, 2011.

Kuriakose, T., D. A. Hilt, and Jackwood, M. W. , Multiplex microsphere assay for simultaneous detection of all avian influenza viruses and differentiation of H5, H7, N1 and N2 subtypes. Avian Dis. 56:90-96, 2012.

Cook, J. K. A., Jackwood, M. W. and R. C. Jones. The long view: 40 years of infectious bronchitis research. Avian Path. 41:239-250, 2012.

Toro, H., V. L. van Santen and Jackwood, M. W. . Genetic diversity and selection regulates evolution of infectious bronchitis virus. Avian Dis. 56:449-455, 2012.

Jackwood, M. W. , D. Hall and A. Handel. Molecular evolution and emergence of avian gammacoronaviruses. Infection, Genetics and Evolution. 12:1305-1311, 2012.

Jackwood, M. W. Review of infectious bronchitis virus around the world. Avian Dis. 56:634-641, 2012.

Banat, G. R., S. Tkalcic, J. A. Dzielawa, Jackwood, M. W. , M. D. Saggese, L. Yates, R. Kopulos, W. E. Briles, and E. W. Collisson. Association of the chicken MHC B haplotypes with resistance to avian coronaviruses. Developmental and Comparative Immunology. 39:430-437, 2013.

Phillips, J. E., D. A. Hilt and Jackwood, M. W. . Comparative sequence analysis of full-length genome of FIPV at different tissue passage levels. Virus Genes. 47:490-497, 2013.

Roh, H-J., D A. Hilt, S. M. Williams and Jackwood, M. W. . Evaluation of Infectious Bronchitis Virus Arkansas-type Vaccine Failure in Commercial Broilers. Avian Dis. 57:248-259, 2013.

Roh, H-J., D. A. Hilt and Jackwood, M. W. . Simultaneous detection of five major serotypes of avian coronavirus by a multiplex microsphere based assay. J. Vet. Diagn. Invest. 25:458-466. 2013.

Roh, H-J., B. J. Jordan, D. A. Hilt, Jackwood, M. W. , Detection of infectious bronchitis virus using real time quantitative RT-PCR and correlation with virus detection in embryonated eggs. In Press. Avian Dis. 58:398-403, 2014.

Jordan, B. J., D. A. Hilt, R. Poulson, D. E. Stallknecht, and Jackwood, M. W. . Identification of avian coronavirus in wild aquatic birds of the central and eastern USA. J. Wildlife Diseases. 51:218-221, 2015.

Roh, H-J., B. J. Jordan, D. A. Hilt, M. B. Ard, and Jackwood, M. W. , Hatchery Spray Cabinet Administration Does Not Damage Avian Coronavirus Infectious Bronchitis Virus Vaccine Based on Analysis by Electron Microscopy and Virus Titration. Avian Dis. 59:149-152, 2015.

Kapczynski D.R., M. Esak, K.M. Dorsey, H. Jiang, Jackwood, M. W. , M. Moraes, Y, Gardin. Vaccine protection of chickens against antigenically diverse H5 highly pathogenic avian influenza isolates with a live HVT vector vaccine expressing the influenza hemagglutinin gene derived from a clade 2.2 avian influenza virus. Vaccine. Epub ahead of print.

J Jackwood, M. W. , B. J. Jordan, H-J. Roh, D. A. Hilt and S. M. Williams. Evaluating protection against infectious bronchitis virus by clinical signs, ciliostasis, challenge virus detection and histopathology. Avian Dis. 59:368-374, 2015.

Valastro, V., E. C. Holmes, P. Britton, A. Fusaro, Jackwood, M. W. , G. Cattoli, and I. Monne. S1 gene-based phyogeny of infectious bronchitis virus: An attempt to harmonize virus classification. Infection, Genetics and Evolution, 39, 349-364, 2016.

Leyson, C., M. Franca, Jackwood, M. W. , B. Jordan. Polymorphisms in the S1 spike glycoprotein of Arkansas-type infectious bronchitis virus (IBV) show differential binding to host tissues and altered antigenicity. Virology. 498:218-225, 2016.

Leyson, C., D.A. Hilt, B. J. Jordan, Jackwood, M. W. , Minimum infectious dose determination of the ArkDPI infectious bronchitis virus vaccine delivered by hatchery spray cabinet. Avian Dis. 61:123-127, 2017.

Leyson, C., B. J. Jordan, Jackwood, M. W. , Insights from molecular structure predictions of the infectious bronchitis virus S1 spike glycoprotein. Infection, Genetics and Evolution. 46:124-129. 2016.

Jackwood, M. W. and D-H Lee. Different evolutionary trajectories of vaccine-controlled and non-controlled avian infectious bronchitis viruses in commercial poultry. PLoS ONE 12:e0176709. 2017. https://doi.org/10.1371/journal.pone.0176709

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