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Department of Infectious Diseases

Melinda Brindley

PhD
Assistant Professor
Department of Population Health
Email: .(JavaScript must be enabled to view this email address)


Educational Background

  • BS (2002) Microbiology, Arizona State
  • PhD (2007) Microbiology, University of Iowa

Research Interests

The focus of our laboratory is the characterization of enveloped virus entry. Specifically we are interested in the mechanism of virus-cellular fusion utilizing arenaviruses as our model. We perform structure-functional analyses on the Old World arenavirus glycoprotein complex. As we define the functional micro-domains within the protein, we hope to provide new targets for therapeutics and vaccine development.


Awards

  • ASV 2010 Postdoctoral Travel Award, 2010
  • Molecular Mechanisms of Microbial Pathogenesis, NIH T32 AI007470 (postdoctoral fellowship), 2008
  • Helen C. Levitt Center Travel Award, 2008
  • CROI Young Investigator Awardee, 2008

Selected Publications

Brindley MA*, Chaudhury S*, Plemper RK.  Measles Virus Glycoprotein Complexes Preassemble Intracellularly and Relax during Transport to the Cell Surface in Preparation for Fusion.  J Virol. 2015 Jan 15;89(2):1230-41. PMID: 25392208 (*authors contributed equally)

Brindley MA, Plattet P, Plemper RK. Efficient replication of a paramyxovirus independent of full zippering of the fusion protein six-helix bundle domain.  Proc Natl Acad Sci U S A. 2014 Sep 9;111(36):E3795-804. PMID: 25157143

Kiss G, Chen X, Brindley MA, Campbell P, Afonso CL, Ke Z, Holl JM, Guerrero-Ferreira RC, Byrd-Leotis LA, Steel J, Steinhauer DA, Plemper RK, Kelly DF, Spearman PW, Wright ER. Capturing enveloped viruses on affinity grids for downstream cryo-electron microscopy applications. Microsc Microanal. 2014 Feb;20(1):164-74. PMID: 24279992

Brindley MA*, Suter R*, Schestak I, Kiss G, Wright E, Plemper RK. A stabilized headless measles virus attachment protein stalk efficiently triggers membrane fusion. J Virol. 2013 Aug 21. PMID: 23966411 (*authors contributed equally)

Tahara M, Ohno S, Sakai K, Ito Y, Fukuhara H, Komase K, Brindley M, Rota P, Plemper R, Maenaka K, and Takeda M. The receptor-binding site of the measles virus hemagglutinin protein itself constitutes a conserved neutralizing epitope. J Virol. 2013 Mar;87(6):3583-6. PMID: 23283964

Tahara M, Ito Y, Brindley MA, Ma X, He J, Xu S, Fukuhara H, Sakai K, Komase K, Rota PA, Plemper RK, Maenaka K, Takeda M. Functional and structural characterization of neutralizing epitopes of measles virus hemagglutinin protein. J Virol. 2013 Jan; 87(1):666-75. PMID: 23115278

Ader N, Brindley M, Avila M, Orvell C, Horvat B, Hiltensperger G, Schneider-Schaulies J, Vandevelde M, Zurbriggen A, Plemper RK, Plattet P. Active membrane fusion triggering mechanism by morbillivirus attachment protein. J Virol. 2013 Jan;87(1):314-26. PMID: 23077316

Brindley MA, Takeda M, Plattet P, Plemper RK. Triggering the measles virus membrane fusion machinery. Proc Natl Acad Sci U S A. 2012 Oct 30;109(44):E3018-27. PMID: 23027974

Ader N, Brindley MA, Avila M, Origgi FC, Langedijk JP, Orvell C, Vandevelde M, Zurbriggen A, Plemper RK, Plattet P. Structural rearrangements of the central region of the morbillivirus attachment protein stalk domain trigger F protein refolding for membrane fusion. J Biol Chem. 2012 May 11;287(20):16324-34. PMID: 22431728

Plemper RK, Brindley MA, Iorio RM. Structural and mechanistic studies of measles virus illuminate paramyxovirus entry. PLoS Pathog. 2011 Jun;7(6). PMID: 21655106 review

Kondratowicz AS, Lennemann NJ, Sinn PL, Davey RA, Hunt CL, Moller-Tank S, Meyerholz DK, Rennert P, Mullins RF, Brindley M, Sandersfeld LM, Quinn K, Weller M, McCray PB Jr, Chiorini J, Maury W. From the Cover: T-cell immunoglobulin and mucin domain 1 (TIM-1) is a receptor for Zaire Ebolavirus and Lake Victoria Marburgvirus. Proc Natl Acad Sci U S A. 2011 May 17;108(20):8426-31. PMID: 21536871 Featured article.

Brindley MA*, Hunt CL*, Kondratowicz AS, Bowman J, Sinn PL, McCray PB Jr, Quinn K, Weller ML, Chiorini JA, Maury W. Tyrosine kinase receptor Axl enhances entry of Zaire ebolavirus without direct interactions with the viral glycoprotein. Virology. 2011 Jul 5;415(2):83-94. PMID: 21529875 (*authors contributed equally)

Oh C, Price J, Brindley MA, Widrlechner MP, Qu L, McCoy JA, Murphy P, Hauck C, Maury W. Inhibition of HIV-1 infection by aqueous extracts of Prunella vulgaris L. Virol J. 2011 Apr 23;8:188. PMID: 21513560

Brindley MA and Plemper RK. Blue Native PAGE and Biomolecular Complementation Reveal a Tetrameric or Higher-Order Oligomer Organization of the Physiological Measles Virus Attachment Protein H. J Virol. 2010 Dec; 84(23):12174-84. PMID: 20861270 Featured article.

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