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Department of Infectious Diseases

Rick L. Tarleton

Rick L. Tarleton

PhD
Distinguished Research Professor, Department of Cellular Biology
UGA Athletic Association Distinguished Professor
Email: .(JavaScript must be enabled to view this email address)


Research Interests

  • Cells and Disease
  • Cells in Infection and Immunity

Selected Publications

Gretchen Cooley, R. Drew Etheridge, Courtney Boehlke, Becky Bundy, D. Brent Weatherly, Todd Minning, Matthew Haney, Miriam Postan, Susana Laucella, and Rick L. Tarleton 2008. High throughput selection of effective serodiagnostics for Trypanosoma cruzi infection. PLoS Neglected Tropical Diseases, in press.

Bixby L.M. and Tarleton R.L. Carleton. 2008. Stable CD8+ T cell memory during persistent Trypanosoma cruzi infection. J Immunol. 15;181(4):2644-50.

Bustamantes J.M., Bixby L.M., and Tarleton R.L. 2007. Drug induced cure drives conversion to a stable and protective CD8+ T central memory response in chronic Chagas disease. Nat. Med.; 14(5):542-550. Tarleton R.L. , Reithinger R., Urbina J.A., Kitron U., Gurtler R.E. 2007. The challenges of Chagas Disease – a grim outlook or glimmer of hope. PloS Med; 4(12):e332

Tarleton R.L. 2007. Immune system recognition of Trypanosoma cruzi. Curr Opin Immunol; 19(4):430-434.

Martin D.L., M. Postan, P. Lucas, R. Gress, R.L. Carleton. 2007. TGF-beta regulates pathology but not tissue CD8+ T cell dysfunction during experimental Trypanosoma cruzi infection. Eur J Immunol. 37(10): 2764- 2771.

Padilla A., Xu D., Martin D., Tarleton R. 2007 Limited Role for CD4+ T-Cell Help in the Initial Priming of Trypanosoma cruzi-Specific CD8+ T Cells. Infect Immun.; 75(1):231-235.

Kotner J, Tarleton R . 2007. Endogenous CD4+CD25+ Regulatory T Cells Have Limited Role in Control of Trypanosoma cruzi Infection in Mice. Infect Immun. 75(2):861-869.

Atwood J.A., Minning T., Ludolf F., Nuccio A., Weatherly D.B., Alvarez-Manilla G., Tarleton R. , Orlando R. 2006. Glycoproteomics of Trypanosoma cruzi trypomastigotes using subcellular fractionation, lectin affinity, and stable isotope labeling. J. Proteome Res. 5(12):3376-3384.

Martin, D. L., D. B. Weatherly, S.A. Laucella, M. A. Cabinian, M. T. Crim, S. Sullivan, M. Heiges, S. H. Craven, C. S. Rosenberg, M. H. Collins, A. Sette, M. Postan, R. L. Tarleton . 2006. CD8+ T-Cell responses to Trypanosoma cruzi are highly focused on strain-variant trans-sialidase epitopes. PloS Pathog; 2(8):e77.

Albareda, M.C., S.A. Laucella, M.G. Alvarez, A.H. Armenti, G. Bertochi, R.L. Carleton and M. Postan. 2006. Trypanosoma cruzi modulates the profile of memory CD8+ T cells in chronic Chagas disease patients. Int Immunol; 18(3):465-471.

El-Sayed, N.M., P.J. Myler, D.C. Bartholomeu, D. Nilsson, G. Aggarwal, A.N. Tran, et al. 2005. The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas disease. Science. 309:409-415. Atwood, J.A. III, D.B. Weatherly, T.A. Minning, B. Bundy, C. Cavola, F.R. Opperdoes, R. Orlando, R.L. Tarleton . 2005. The Trypanosoma cruzi proteome. Sciences. 309(5733):473-476.

Weatherly, D.B. J.A. Atwood III, T.A. Minning, C. Cavola, R.L. Carleton , R. Orlando. 2005. A heuristic method for assigning a false-discovery rate for protein identification from Mascot database search results. Mol. Cell Proteomics. 4(6):762-772.

Martin, D.L. and R.L. Carleton . 2005. Antigen-specific T cells maintain an effector memory phenotype during persistent Trypanosoma cruzi infection. J. Immunol. 174(3):1594-1601.

Cummings, K.L, and R.L. Carleton . 2004. iNOS is not essential for control of Trypanosoma cruzi infection in mice. Infection and Immunity. 72(7):4081-4089.

Laucella, S.A., D. Martin, M.C. Albareda, B.H. Fralish, N. Prado, A.H. Armenti, R.J. Viotti, S.N. Torres, B. Loccoco, M. Postan, R.L. Carleton . 2004. Frequency of IFN-gamma-producing T cells specific for Trypanosoma cruzi inversely correlates with disease severity in chronic human Chagas disease. Journal of Infectious Diseases. 89(5):909-918.

Cummings, K.L. and R. L. Tarleton . 2003. Rapid quantitation of Trypanosoma cruzi in host tissue by real-time PCR. Molecular and Biochemical Parasitology. 129:53-59.

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