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Department of Infectious Diseases

M. Stephen Trent

PhD
Professor, Department of Infectious Diseases
UGA Foundation Distinguished Professor
Email: .(JavaScript must be enabled to view this email address)


Educational Background

  • 2000-2002                 Postdoctroal Fellow (NIH Ruth L. Kirschstein NRSA)
                                    Department of Biochemistry
                                    Duke University, Durham, NC
  • 1994-1999                 PhD, Biochemistry and Molecular Biology
                                    James H. Quillen College of MedicineEast
                                    Tennessee State University
  • 1990-1994                 BA, Chemistry
                                    University of Virginia at Wise

Awards

  • 2016 Zoetis Award for Research Excellence
  • 2016-2022. Permanent Member, NIH BACP Study Section
  • 2015 Awarded UGA Foundation Distinguished Professor
  • 2015 Distinguished Alumni Award, James H. Quillen College of Medicine
  • 2014-Present Fellow of the American Academy of Microbiology
  • 2013-Present Editorial Board, Journal of Innate Immunity
  • 2012 College of Natural Sciences Teaching Excellence Award
  • 2012-Present Editorial Advisory Board, Molecular Microbiology
  • 2011-2015 Editorial Board, Journal of Biological Chemistry
  • 2009-2014 Associate Editor, BMC Microbiology
  • 2008 Alois Nowotny Award
  • 2003-2005 NIAID Research Scholar Development Award
  • 1990-1994 Theo-Gibson Scholar, University of Virginia
  • 1992-1994 American Institute of Chemistry Scholar, University of Virginia

Selected Publications

  • 1. Cullen, T. W. and Trent, M. S. 2010. A link between the assembly of flagella and lipopoligosaccharide of the Gram-negative bacterium Campylobacter jejuni. PNAS. 107: 5160-5.

    Highlighted in Commentary (Nature Rev. Micro., 8: 312-313).

  • 2. Giles, D. K., Hankins, J. V., Guan, Z., and Trent, M. S. 2011. Remodeling of the Vibrio cholerae membrane by incorportation of exogenous fatty acids from host and acquatic environments. Mol. Micro. 79: 716-28.
  • Faculty of 1000

  • 3. Cullen, T. W., Giles, D. K., Wolf, L. N., Ecobichon, C., Boneca, I. G. and Trent, M. S. 2011. Helicobacter pylori versus the host: Remodeling of the bacterial outer membrane is required for survival in the gastric mucosa. PLoS Pathogens. 7: 1-18.
  • Listed as a most viewed article of the PLoS Pathogens Issue Faculty of 1000, 2 evaluations Highlighted by ASM Microbe World (02/27/2012) Highlighted by Scientific American (02/26/2012)

  • 4. Hankins, J. V., Madsen, J. W., Giles, D. K., Brodbelt, J. S., and Trent, M. S. 2012. Amino acid addition to Vibrio cholerae LPS establishes a link between surface remodeling in Gram-negative and Gram-positive bacteria. PNAS. 109: 8722-7.
  • Highlighted in by Nature Micro. Rev. (2012, 10: 442-443) Faculty of 1000, listed as a Exceptional (10), 2 evaluations Highlighted by ASM Microbe (2012, 7: 389-390) Highlighted by The ASM Podcast TWIM (This week in microbiology, #35) Highlighted by ASBMB, The Lipid Corner

  • 5. Needham, B. D., Carroll, S., Giles, D. K., Georgiou, G., Whiteley, M. and Trent, M. S. 2013. Modulating the innate immune response by combinatorial engineering of endotoxin. PNAS. 110: 1464-9.
  • Highlighted by Science (AAAS)-Editor’s Choice, Translational Medicine (2013, 5: 170) Highlighted by The Scientist (02/10/13 issue) Highlighted by Future Microbiology (8: 307-310, 2013) Faculty 1000 Highlighted by ASM Microbe World (01/16/2013 Highlighted by NPR (National Public Radio) Highlighted by Science Daily

  • 6. Needham, B. D. and Trent, M. S. 2013. Fortifying the barrier: the impact of lipid A remodeling on bacterial pathogenesis. Nature Micro Review. 11: 467-81.
  • 7. Pride, A. P., Herrera, C. M., Guan, Z., Giles, D. K. and Trent, M. S. 2013. The outer surface lipoprotein VolA mediates utilization of exogenous lipids by Vibrio cholerae. MBio. 4(3):e00305-13.
  • 8. Rubin, E. J., O’Brien, J. P., Ivanov, P. L., Brodbelt, J. S. and Trent, M. S. 2014. Identification of a broad family of lipid A late acyltransferases with non-canonical substrate specificity. Mol. Micro. 91: 887-99.
  • Highlighted in Commentary (Mol. Micro. 2014, 91: 858-61)

  • 9. Whitfield C. and Trent, M. S. 2014. Biosynthesis and Export of Bacterial Lipopolysaccharides. Annual Rev. of Biochem. 83:99-128.
  • Faculty of 1000

  • 10. Henderson, J. C., Fage, C. D., Cannon, J. R., Brodbelt, J. S., Keatinge-Clay, A. T. and Trent, M. S. 2014. Antimicrobial peptide resistance of Vibrio cholerae results from LPS modification pathway related to non-ribosomal peptide synthetases. ACS Chemical Biology. 9:2382-92.
  • 11. Herrera, C. M., Crofts, A. A., Henderson, J. C., Pingali, S. C., Davies, B. W. and Trent, M. S. 2014. The Vibrio cholerae VprA-VprB Two-Component System Controls Virulence through Endotoxin Modification. mBio. 5(6):302283-14.
  • 12. Boll, J. B., Tucker, A. T., Klein, D. R., Beltran, A. M., Brodbelt, J. S., Davies, B. W. and Trent, M. S. 2015. Reinforcing the cell surface, lipid A acylation in Acinetobacter baumannii. MBio. 6(3):e00478-15.
  • 13. Henderson, J. C., Zimmerman, S. M., Crofts, A. A., Boll, J. M., Kuhns, L. G., Herrera, C. M. and Trent, M. S. 2016. The Power of Asymmetry: Architecture and Assembly of the Gram-Negative Outer Membrane Lipid Bilayer. Annu. Rev. Microbiol. 70:255-78.
  • 14. Boll, J. M., Crofts, A. A., Peters, K., Cattoir, V., Vollmer, W., Davies, B. W. and Trent, M. S. 2016. A pencillin binding protein inhibits selection of colistin-resistant, lipooligosaccharide-deficient Acinetobacter baumannii. PNAS. 113(41):E6228-E623.7

    Faculty of 1000 Highlighted by UGA News and Research Highlighted by Technology.org and Health Medicine Network Highlighted by DRUG Discovery & Development

  • 15. Petrou, V. I., Herrera, C. M., Schultz, K. M., Clarke, O. B., Vendome, J., Tomasek, D., Banerjee, S., Rajashankar, K. R., Kloss, B., Kloppmann, E., Rost, B., Klug, C. S., Trent, M. S., Shaprio, L. and Mancia, F. 2016. Structures of aminoarabionse transferase ArnT suggest a molecular basis for resistance to polymyxin-class antibiotics. Science. 351: 608-12.

    Faculty of 1000, 3 recommendations

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