Zhen Fu DVM, PhD
Interim Department Head
- DVM (1981) Huazhong Agricultural University, China
- PhD (1988) Massey University, New Zealand
- Neuropathogenesis of rabies
- Functional genomics and proteomics
- Development of anti-viral vaccines, monoclonal antibodies, and agents
- Regulation of rabies virus transcription and replication
Dr. Fu’s research is supported by funding from National Institutes of Health (AI51560 and HHSN266200700006C).
- Virology and Viral Pathogenesis
Dr. Fu has found that attenuated rabies virus activates, but pathogenic rabies virus evades, the host innate immune responses including activation of IFN pathways, induction of inflammation and apoptosis. He has further found that evasion of the host immune responses of the pathogenic virus is due to restriction of the G protein expression. These studies have led to the creation of infectious virus clones that express innate immune molecules. These viruses have the ability to induce innate and enhance the adaptive immune responses and thus can be developed as avirulent rabies virus vaccines.
Furthermore, Dr. Fu is involved in the research of neuropathogenesis of rabies as well as other virus infections such as respiratory syncytial virus, human metapneumovirus, and influenza virus. Dr. Fu is part of the NIAID Center of Excellence for Influenza Research and Surveillance.
- Zhao L., Toriumi H, Kuang Y, Chen H, Fu ZF 2009. The roles of chemokines in rabies virus infection: over-expression may not always be beneficial. J. Virol. 83: 11808-11818.
- Kuang Y, Lackay SN, Zhao L, Fu ZF 2009. Role of chemokines in the enhancement of BBB permeability and inflammatory infiltration after rabies virus infection. Virus Res. 144:18-26.
- Liu Y, Haas D, Poore S, Isakovic S, Gahan M, Mahalingam S, Fu ZF, Tripp RA 2009. Human metapneumovirus establishes persistent infection in the lungs of mice and is reactivated by glucocorticoid treatment. J. Virol. 83:6837-48.
- Zhang, YZ., Xiong, CL., Lin, XD., Zhou, DJ., Jiang, RJ., Xiao, QY., Xie, XY., Yu, XX., Tan, YJ., Li, MH., Ai, QS., Zhang, LJ., Zou, Y., Huang, C., Fu, ZF. 2009. Genetic Diversity of Chinese Rabies Viruses: Evidence for the Presence of Two Distinct Clades in China. Infect Genet Evol. 9:87-96.
- Zhang, Y-Z., Xiong, C-L., Kuzmin, I., Niezgoda, M, Fu, Z. F., Rupprecht, CE. 2008. Investigation of the role of healthy dogs as carriers of rabies virus. Vector-Borne and Zoonotic Diseases. 8:313-20.
- Zhang, Y-Z., Yan, Y-Z., Zou, Y., Li Y., Li, M-H., Chen, X., Chen, H-X., Yao, L-S., Hui, G-W., Du, Z-S., Fu, Z. F. 2007. Detection of phylogenetically distinct Puumala-like viruses from red-grey vole Clethrionomys rufocanus in China. J. Med. Virol. 79:1208-1218.
- Dhingra, V., Li, Xi., Liu, Y., Fu, Z. F. 2007. Proteomic profiling reveals that rabies virus infection results in differential expression of host proteins involved in ion homeostasis and synaptic physiology in the central nervous system. J. NeruoVirol. 13:107-17.
- Sarmento, L., Tseggai, T., Dhingra, V., Fu, Z. F. 2006. Rabies virus-induced apoptosis involves caspase-dependent and caspase-independent pathways. Virus Res., 121:144-151.
- Li, X., Fu, Z. F., Alvarez, R., Tripp, R.A. 2006. Respiratory Syncytial Virus Infects Neuronal Cells and Processes that Innervate the Lung by a RSV G Protein Dependent Process. J. Virol. 80:537-40.
- Sarmento, L., Li, X., Howerth, E., Jackson, A. C., Fu, Z. F. 2005. Glycoprotein-mediated induction of apoptosis limits the spread of attenuated rabies viruses in the CNS of mice. J. NeuroVirol. 11:571-81.
- Zhang, Y-Z., Xiong, C-L., Xiao, D-L., Jiang, R-J., Wang, Z-X., Zhang, L-Z., Fu, Z. F. 2005. Human Rabies in China in the past 54 years. EID, 11:1983-1984.
- Wang, Z.W., Wang, Y, Sarmento, L., Li, E.X., Dhingra, V., Tseggai, T., Jiang, B., Fu, Z. F. 2005. Pathogenic rabies virus evades, while attenuated rabies virus activates, the host innate immune responses in the CNS. J. Virol. 79:12554-12565.
- Information on additional publications by Dr. Fu can be found at PubMed.