Comparison of three vascular closure techniques in dogs undergoing cardiac catheterization

Comparison of Vascular Closure Techniques in Dogs Undergoing Percutaneous Transcatheter Intervention

Lauren Markovic, DVM, DACVIM (Cardiology faculty)
Amanda Coleman, DVM, DACVIM (Cardiology faculty)
Arianne Fabella, DVM (Cardiology resident)

If interested, please have your primary veterinarian request additional information through the Clinical Trials Coordinator Lisa Reno at 706-296-7818 or the UGA Cardiology service by calling the small animal referral coordinator at 706-542-5362.

Study description:
Interventional cardiovascular therapeutics is a growing field in veterinary medicine. Percutaneous transcatheter intervention is a technique used for right sided heart catheterization. After access, vascular sites must be closed to stop any bleeding. This study investigates 3 vascular closure techniques with respect to providing rapid hemostasis, minimizing vascular access complications, maintaining vessel patency, and being tolerated well by the patient.
Dogs undergoing cardiac catheterization using a percutaneous venous approach and meeting eligibility criteria will be randomly assigned to one of 3 vascular closure techniques; manual compression, suture-based, or vascular closure device. All dogs will have a postoperative visit 8-12 weeks after the catheterization procedure for a vein ultrasound at the site of the closure.

Inclusion criteria:

  • Percutaneous access during right heart catheterization
  • Appropriate sized introducer for the vascular closure device group

Exclusion criteria:

  • Dogs currently taking anti-coagulant therapy
  • Dogs with exposure to vitamin K antagonists within the last 6 months
  • Dogs with known primary or secondary disorder of hemostasis
  • Any dog where surgical cut-down is required for vascular access

The study pays for the cost of the device/method used for catheterization closure, in addition to the vein ultrasound 8-12 weeks post-operatively. Clients are responsible for all other costs pertaining to their dog’s diagnosis and cardiac procedure.

Duration of study:
The study is currently OPEN and accepting patients.

Potential benefits to veterinary medicine:
This research is beneficial to canine patients undergoing vascular catheterization for either diagnostic or therapeutic purposes. Reduction in vascular complications poses significant potential reduction in perioperative morbidity. Results will be useful for veterinary professionals and preclinical researchers who perform vascular access techniques in animals.

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