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Alex MacLean

Alex MacLean

The University of Georgia
College of Veterinary Medicine
Class of 2020

Research Interests

The effects of oral Bisphenol exposure on ovary and egg development in adult chickens

Alex MacLean, Fatma Eldefrawy, and Tai L. Guo

Department of Veterinary Biosciences and Diagnostic Imaging, College of Veterinary Medicine, University of Georgia, Athens, GA (MacLean, Guo); Department of Anatomy and Embryology, Faculty of Veterinary Medicine, Alexandria University, Alexandria, Egypt (Eldefrawy)

Understanding the impacts of endocrine disrupting chemicals (EDCs) on synthesis, secretion, transport, and metabolism of natural hormones is essential in determining the risks posed by these compounds on human, animal and environmental health. Bisphenol analogues, including Bisphenol A (BPA) and S (BPS), are among the most common commercial EDCs. BPA is used in polycarbonate plastics, dental resins, and the lining of metal food cans; it is also one of the most potent environmental xenoestrogens. BPS has emerged as an alternative to BPA in the midst of rising consumer health concerns and has proven to be even less biodegradable. Few studies have been completed concerning the endocrine disrupting potential of BPS. Chickens serve as an ideal and commercially relevant animal model for endocrine disruption due to their well characterized genome and physiology. After oral exposure to 50 mg/kg body weight of bisphenols or the vehicle (corn oil) over a 10-week period, egg quality characteristics including shell thickness, weight, calcium concentration and appearance were determined. RNA isolation was performed on ovarian follicular tissues, and RNA sequencing will be conducted to determine dynamic gene expression. Preliminary results suggested significant differences in egg shell thickness between the BPA treated group and the other treatments. BPA treatment also produced more shell deformities, including ridges and pimples, than BPS and the vehicle. Further studies will be conducted to determine the distinct effects of BPA and BPS at key developmental stages and their genotoxic potential.

Research Grant: This study was supported by the Egyptian government scholarship for Ms. Fatma Abdelhady Eldefrawy, and in part by NIH R21ES24487 (TL Guo).

Student Support: NIH Office of Research Infrastructure Programs, Grant Number 2T35OD010433-11

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