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GVSP

Cook English

Cook English

The University of Georgia
College of Veterinary Medicine
Class of 2020


Research Interests

Evaluation of a nutraceutical for management of lower urinary tract disease in healthy cats
 

Cook F. English, Ashley P. Shaw Green, Sherry K. Cox, Joe W. Bartges

Affiliations: Small Animal Medicine and Surgery (English, Green, Bartges), College of Veterinary Medicine, The University of Georgia, Athens, GA; Department of Biomedical and Diagnostic Services (Cox), College of Veterinary Medicine, The University of Tennessee, Knoxville, TN

Idiopathic cystitis and urolithiasis are common causes of feline lower urinary tract signs (LUTS). Prevention and/or alleviation are often accomplished by diluting urine, reducing concentration of calculogenic constituents, and inducing more frequent urination. Traditional therapies are increasingly supplemented with nutraceuticals, although research is limited. We evaluated Tripsy, an herbal supplement recommended for cats with LUTS, in a placebo crossover study of seven healthy male cats aged 10 months to 5 years. We hypothesized that cats would produce larger urine volume, have decreased urine saturation for struvite and calcium oxalate, and have different urine metabolomic profiles when receiving Tripsy when compared with placebo. Cats were randomly assigned in a pairwise fashion to an initial treatment for two weeks, followed by a five-day washout period, then crossed over to the other treatment for two weeks. Urine was collected over a 48-hour span at the end of each treatment period. Samples were analyzed for electrolytes, minerals, and creatinine using an automated chemistry analyzer; citrate and oxalate by ion chromatography; pH by electrode; and ammonia by ion-select electrode. Upper limit of metastability was evaluated by addition of ammonium oxalate to urine and quantified by measuring absorbance using spectrophotometry. Relative supersaturation for calcium oxalate and struvite (an estimate of urolith formation potential) was estimated using an iterative program. Results are pending.

Research Grant: Companion Animal Nutrition and Wellness Institute

Student Support: Boehringer Ingelheim; Veterinary Medical Experiment Station, UGA College of Veterinary Medicine

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