Eric R. Lafontaine
Department of Infectious Diseases
- BSc (1991) Medical Biology, Universite du Quebec a Trois Rivieres
- PhD (1997) Microbiology and Infectious Diseases, University of Calgary
About Eric R. Lafontaine
Dr. Eric Lafontaine’s research group is interested in, and has contributed to, the fields of bacterial pathogenesis and host-pathogen interactions for the organisms Moraxella catarrhalis, Burkholderia mallei, and Burkholderia pseudomallei. Moraxella catarrhalis is a human-specific bacterium and causative agent of otitis media in children, sinusitis, and respiratory infections in adult patients with chronic obstructive pulmonary disease. Little is known about pathogenesis by M. catarrhalis and there is currently no vaccine for the organism. Burkholderia mallei, the causative agent of the highly contagious zoonotic disease glanders, is endemic to many parts of the world and is considered a re-emerging biosafety and biosecurity threat. Melioidosis, which is caused by Burkholderia pseudomallei, is recognized as a global emerging tropical disease. The U. S. Federal Select Agent Program also classifies these Burkholderia species as Tier 1 agents (highest risk level) and no vaccine exists to reduce the risk of the life-threatening infections they cause. Dr. Lafontaine’s group has developed and validated 4 animal models, namely a chinchilla model of nasopharyngeal colonization to study M. catarrhalis, a mouse model of aerosol infection to study B. pseudomallei and B. mallei, an experimental model of equine glanders to study B. mallei, and a marmoset intranasal model of infection to studyB. mallei. These models are being used to study pathogenesis by the organisms, examine the role of surface antigens in virulence, and develop medical countermeasures.
Adherence factors from Moraxella catarrhalis, Burkholderia mallei and B. pseudomallei
- Verhaegh SJ, Stol K, de Vogel CP, Riesbeck K, Lafontaine ER, Murphy TF, van Belkum A, Hermans PW, Hays JP. Comparative analysis of the humoral immune response to Moraxella catarrhalis and Streptococcus pneumoniae surface antigens in children suffering from recurrent acute otitis media and chronic otitis media with effusion. Clin Vaccine Immunol. 2012 Jun;19(6):914-8.
- Verhaegh SJ, de Vogel CP, Riesbeck K, Lafontaine ER, Murphy TF, Verbrugh HA, Jaddoe VW, Hofman A, Moll HA, van Belkum A, Hays JP. Temporal development of the humoral immune response to surface antigens of Moraxella catarrhalis in young infants. Vaccine. 2011 Aug 5;29(34):5603-10.
- Balder R, Lipski S, Lazarus JJ, Grose W, Wooten RM, Hogan RJ, Woods DE, Lafontaine ER. Identification of Burkholderia mallei and Burkholderia pseudomallei adhesins for human respiratory epithelial cells. BMC Microbiol. 2010 Sep 28;10:250.
- Balder R, Krunkosky TM, Nguyen CQ, Feezel L, Lafontaine ER. Hag mediates adherence of Moraxella catarrhalis to ciliated human airway cells. Infect Immun. 2009 Oct;77(10):4597-608.
- LaFontaine ER, Snipes LE, Bullard B, Brauer AL, Sethi S, Murphy TF. Identification of domains of the Hag/MID surface protein recognized by systemic and mucosal antibodies in adults with chronic obstructive pulmonary disease following clearance of Moraxella catarrhalis. Clin Vaccine Immunol. 2009 May;16(5):653-9.
- Balder R, Lafontaine ER. Laboratory Maintenance of Moraxella catarrhalis. Curr Protoc Microbiol. 2008 Nov;Chapter 6:Unit 6B.1.
- Bullard B, Lipski S, Lafontaine ER. Regions important for the adhesin activity of Moraxella catarrhalis Hag. BMC Microbiol. 2007 Jul 3;7:65.
- Akimana C, Lafontaine ER. The Moraxella catarrhalis outer membrane protein CD contains two distinct domains specifying adherence to human lung cells. FEMS Microbiol Lett. 2007 Jun;271(1):12-9. Epub 2007 Mar 28.
- Balder R, Hassel J, Lipski S, Lafontaine ER. Moraxella catarrhalis strain O35E expresses two filamentous hemagglutinin-like proteins that mediate adherence to human epithelial cells. Infect Immun. 2007 Jun;75(6):2765-75. Epub 2007 Mar 19.