due to decreased intravascular osmotic pressure
|This diagram depicts
the pathogenesis of edema formation due to decreased plasma colloidal
osmotic pressure. Capillary blood contains a decreased quantity
of colloids (protein-white circles) due to either decreased hepatic synthesis
of these proteins or increased protein loss through the kidney or gastrointestinal
tract. As a result of the hypoproteinemia, fluid and crystalloids fail
to be reabsorbed at the venous end of the capillary and accumulate in
the interstitium as edema.
serum albumin decreases intravascular oncotic pressure and causes
||Most of this
dogs liver has been replaced by neoplastic tissue. This affects
serum protein content by compromising the livers ability
to synthesize albumin. With decreased production of albumin the plasma colloidal
osmotic pressure decreases and edema occurs.
commonly occurring conditions that may cause hypoproteinemia are
renal and gastrointestinal disease. In these diseases, hypoproteinemia
occurs due to loss of protein through urine (protein-losing nephropathy
such as amyloidosis) or feces (protein-losing enteropathy such
as intestinal lymphosarcoma).