Note the fibrinous thrombi on the aortic valves of this dog’s heart. This is called vegetative valvular endocarditis.
Turbulence around the valves results in endothelial damage, platelet aggregation, and then, as bacteria happen to cruise by, they find this a great place to grow, so the thrombi become SEPTIC.
Inflammation causes cytokine release that stimulates tissue factor release by endothelial cells. Damaged endothelial cells also release tissue factor. Activation of the coagulation system results in fibrin deposition and thrombi enlarge.
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