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Infectious Diseases News

New findings link estrogen and T cell immune response to autoimmune inflammation

Women are more prone to the development of autoimmune diseases. The female hormone estrogen is likely to affect the immune system. A team of scientists from Turku Center for Biotechnology and University of Georgia reported new findings related to the involvement of estrogen hormone receptor in autoimmune diseases.

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Harvill Group Awarded New Grant to Study Transmission

The grant funds new work seeking to identify exactly which genes transmission requires. Isolating genes of the virulence factor (transmission exopolysaccharide) will aid in determining functions. These complex sugars that bacteria secrete into a capsule around their cell body have unknown transmission-related properties. Dr. Harvill explains, “It takes a lot of energy for bacteria to secrete these large sugars, so they must be doing something important.”

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Dr. Wilkes’ lab research published in Journal of Veterinary Microbiology

Posted by: Noah Hill

Canine distemper virus (CDV) is an RNA virus of the genus Morbillivirus within the family Paramyxoviridae. CDV produces multi-systemic disease in dogs and other terrestrial carnivores. With the development of modified live vaccines in the 1950s and 1960 s, the disease, with a few exceptions, has been successfully controlled. However, recently the cases of CDV in vaccinated dogs have been increasing throughout the world, including the United States. There are many reasons that can lead to vaccine failure, including antigenic differences between the vaccine strains and the currently circulating wild-type strains. Currently, there are at least three genetically different CDV lineages circulating in the US. Therefore, in this study, we evaluated various wild-type CDV and vaccine isolates to determine if the genetic differences observed among various strains result in significant antigenic differences based on changes to the neutralizing epitopes. The results of a cross-neutralization assay revealed that there are antigenic differences among the tested CDV wild-type isolates as well as between the tested isolates and the vaccine strains currently used in the US. Therefore, these results suggest the need to develop an updated CDV vaccine.

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Dr. Wilkes Selected for John M. Bowen Award of Excellence in Animal Biomedical Research

Posted by: CVM

Congratulations to Dr. Rebecca Wilkes on receiving the 2018 John M. Bowen Award of Excellence in Animal/Biomedical Research.

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