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Department of Pathology

Kaori Sakamoto

DVM, PhD, DACVP
Interim Department Head
Associate Professor
Anatomic Pathology
Email: .(JavaScript must be enabled to view this email address)


Educational Background

  • BS (1991) Duke University
  • MLS (1995) North Carolina State University
  • DVM (1999) North Carolina State University
  • MS (2002) Purdue University
  • PhD (2008) Cornell University
  • Diplomate, American College of Veterinary Pathologists (2002)

Research Interests

  • Immunomodulatory effects of mycobacterial cell wall lipids
  • Pathogenesis of granulomatous diseases
  • Intramacrophagic bacterial survival
  • Animal models of granulomatous diseases

Selected Publications

  • Frontera-Acevedo, K., Brown, H.M., Peterson, D.S., Creevy, K., Garner, B., Balsone. N., Dugan, M., Makemson, C., Sellers, L.B., and K. Sakamoto. (2013). Systemic immune response in Cytauxzoon felis-infected domestic cats. Amer J Vet Res, 75(6):901-9.
  • Bowdish, D.M.E, Sakamoto, K., Lack, N.A., Sirugo, G., Newport, M., Gordon, S., Hill, A.V.S., and F.O. Vannberg. (2013). Genetic variants of MARCO are associated with susceptibility to pulmonary tuberculosis in a Gambian population. BMC Medical Genetics, 14:47.
  • ‚ÄčSakamoto, K.. (2012).  The pathology of Mycobacterium tuberculosis infection.  Vet Pathol., 49(3):423-439.
  • Sakamoto, K., Geisel, R.E., Kim, M.J., Wyatt, B.T., Sellers, L.B., Smiley, S., Cooper, A.M., Russell, D.G. and E.R. Rhoades.  (2010).  Fibrinogen regulates the cytotoxicity of mycobacterial trehalose dimycolate in vivo but is not required for cell recruitment, cytokine response, or control of mycobacterial infection.  Infect Immun., 78(3):1004-11.
  • Bowdish, D.M.E.*, Sakamoto, K*, Kim, M., Kroos, M., Mukhopadhyay, S., Leifer, C.A., Tryggvason, K, Gordon, S., and D.G. Russell. MARCO, TLR2, and CD14 are required for macrophage cytokine responses to mycobacterial trehalose dimycolate and Mycobacterium tuberculosisPLoS Pathog 5(6):e1000474. Epub 2009.
  • Equal authorship
  • Van de Walle, G., Sakamoto, K. and N. Osterrieder. (2008). CCL3 and herpesvirus chemokine-binding protein gG modulate pulmonary inflammation and virus replication. J Virol. 82(4):1714-22.
  • Geisel, R.E., Sakamoto, K., Russell, D.G. and E.R. Rhoades. (2005). In vivo activity of released mycobacterial cell wall lipids is due principally to trehalose mycolates. J Immunol. 174(8):5007-15.
  • Khader, S.A., Pearl, J.E., Sakamoto, K., Gilmartin, L., Jelly-Gibbs, D.M., Ghilardi, N., deSauvage, F. and A.M. Cooper. (2005). IL-23 compensates for the absence of IL-12p70 and is essential for the IL-17 response during tuberculosis but is dispensible for protection and antigen-specific IFN-g responses if IL-12p70 is available. J Immunol. 175(2):788-95.
  • Additional publications for Dr. Sakamoto may be found at PubMed.

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