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Department of Pathology

Tamas Nagy

DVM, PhD, DACVP
Associate Professor
Anatomic Pathology
Email: .(JavaScript must be enabled to view this email address)


Educational Background

  • DVM (1994) University of Veterinary Science, Budapest, Hungary
  • PhD (2007) Cornell University, Ithaca, NY
  • Diplomate, American College of Veterinary Pathologists

Teaching Experience

  • Pathology of Laboratory Animals (VPAT 8320)

    Summer 2008 Summer 2010

    Summer 2012

  • NEW Course - Genetically engineered mice in biomedical research (VPAT 8200)

    Teaching TBA


Activities

​Dr. Nagy maintains a research laboratory where he studies mammary carcinogenesis using genetically engineered mice. He is also in charge of the Comparative Pathology Laboratory which provides laboratory animal pathology services to investigators pursuing biomedical research. Please do not hesitate to contact Dr. Nagy regarding future research collaborations.


Research Interests

  • Comparative mammary pathology
  • Pathology of genetically engineered mice
  • Animal models of human diseases

INDEPENDENT RESEARCH

Research in the Nagy laboratory focuses on the role of small G proteins in mammary gland development and carcinogenesis. Various genetically engineered mouse lines are used as models in these investigations.

MAMMARY CARCINOGENESIS

Nagy T, Wei H, Shen TL, Peng X, Liang CC, Gan B, Guan JL. Mammary Epithelial-specific Deletion of the Focal Adhesion Kinase Gene Leads to Severe Lobulo-Alveolar Hypoplasia and Secretory Immaturity of the Murine Mammary Gland. J Biol Chem. 2007 Oct 26;282(43):31766-76. Epub 2007 Aug 23.

Luo M, Fan H, Nagy T, Wei H, Wang C, Liu S, Wicha MS, and Guan J-L. Mammary epithelial-specific ablation of the focal adhesion kinase suppresses tumorigenesis and metastasis by affecting mammary cancer stem/progenitor cells. Cancer Res. 2009 69(2):466-74.

COLLABORATIVE RESEARCH

The Nagy laboratory is actively pursuing various collaborative research projects. These projects are quite diverse, mainly in the areas of infectious diseases (malaria, influenza, and tuberculosis), chemotherapy, and novel drug delivery methods. We provide expert histopathological analysis, digital photography of the histological lesions, and publication assistance for these projects.

MAMMARY CARCINOGENESIS

Guo H-B, Johnson H Randolph M Nagy T Blalock R Pierce M. A specific post-translational modification regulates early events in mammary carcinoma formation. Proc Natl Acad Sci U S A. 107(49):21116-21. Epub 2010 Nov 15.

Guo H-B, Nairn A, Dela Rosa M, Nagy T, Zhao S-Y, Moremen K, Pierce M. Transcriptional regulation of the protocadherin β cluster during her-2- induced mammary tumorigenesis results from altered N-glycan branching. J Biol Chem. 2012 Jun 4. [Epub ahead of print]

IMMUNOPATHOGENESIS OF SEVERE MALARIA DURING PREGNANCY

Project period: 7/5/2007 - 4/30/2012 (5 years) 

Funding agency: NICHD/NIH 

PI: Julie Moore, PhD (Department of Infectious Diseases, UGA) 

Role: Co-Investigator 

Synopsis of the project: The main goal of this work has been to develop a mouse model for malaria during pregnancy using two distinct inbred mouse strains and use this model to identify key soluble immunologic effector molecules that play a role in malaria-induced pregnancy loss.

Poovassery JS, Sarr D, Smith G, Nagy T, Moore JM. Malaria-induced murine pregnancy failure: distinct roles for IFN-gamma and TNF. J Immunol. 2009 183(8):5342-9.

Sarr D, Smith GM, Poovassery JS, Nagy T, Moore JM. Plasmodium chabaudi AS induces pregnancy loss in association with systemic pro-inflammatory immune responses in A/J and C57BL/6 mice. Parasite Immunol. 34(4):224-35, 2012. Epub 2012 Jan 17.

Avery JM, Smith GM, Owino S, Sarr D, Nagy T, Mwalimu S, Matthias J, Kelly LF, Poovassery JS, Middii J, Abramowsky C, and Moore JM. Maternal malaria induces a pro-coagulant and anti-fibrinolytic state that is embryotoxic but responsive to anticoagulant therapy. PLoS One. 2012;7(2):e31090. Epub 2012 Feb 7.

IMMUNOPATHOGENESIS OF SEVERE MALARIA DURING PREGNANCY

Project period: 7/5/2006 – 4/30/2012 

Project number: R01 HD 046860-05 NIH/NICHD 

Funding agency: NICHD/NIH 

Role: Co-Investigator 

PI: Julie M. Moore 

Role: Co-Investigator 

Synopsis of the project: The major goal of this project is to define the soluble immunologic mediators that are produced by pregnant animals in response to malaria that contribute to fetoplacental destruction and pregnancy loss.

PATHOGENESIS OF INFLUENZA INFECTIONS IN MICE AND FERRETS

Humberd Smith J, Nagy T, Barber J, Brooks P, Tompkins SM, and Tripp RA. Aerosol inoculation with a sub-lethal influenza virus leads to exacerbated morbidity and pulmonary disease pathogenesis. Viral Immunol. 24(2):131-42, 2011.

Humberd Smith J, Nagy T, Driskell E, Brooks P, Tompkins MS, Tripp RA. Comparative Pathology in Ferrets Infected with H1N1 Influenza A Viruses Isolated from Different Hosts. J Virol. 85(15):7572-81, 2011. Epub 2011 May 18.

CANCER CHEMOTHERAPY

Aljuffali IA, Mock JN, Cummings BS, Nagy T, and Arnold RD. Enhanced antitumor activity of low-dose continuous administration schedules of topotecan in prostate cancer. Cancer Biol Ther. 2011 Sep 1;12(5). [Epub ahead of print]

J Yeon Kang, LJ. Costyn, T Nagy, EA. Cowan, CD. Oldham, SW. May, RD. Arnold. The antioxidant phenylaminoethyl selenide reduces doxorubicin-induced cardiotoxicity in a xenograft model of human prostate cancer. Arch Biochem Biophys. 515(1-2):112-9, 2011. Epub 2011 Aug 31.

NOVEL DRUG DELIVERY METHODS

Vaka SRK, Murthy SN, Repka MA, and Nagy T. Upregulation of Endogenous Neurotrophin Levels in the Brain by Intranasal Administration of Carnosic Acid. J Pharm Sci. 100:3139–3145, 2011. Epub 2011 Mar 1.

NOVEL METHOD TO TREAT CHRONIC PAIN

Project period: 02/01/2012-01/31/2014 (2 years) 

Project number: R21NS074362-01A1 

Funding agency: NINDS, NIH 

PI: S. Narasimha Murthy, PhD (Research Institute of Pharmaceutical Sciences, The University of Mississippi) 

Role: Co-Investigator 

Synopsis of the project: The main goal of this project is to develop novel intranasal drug delivery systems, incorporated with appropriate barrier modulating agents to deliver Ziconotide to the cerebrospinal fluid.

A NOVEL LIVE INTRANASAL TB VACCINE

Project period: 10/01/2012-09/30/2014 

Funding agency: NIH/SBIR 

PI: Frederick Quinn, PhD (Pathens, Inc., Athens, GA) 

Role: Consultant

BISPHENOL TOXICITY

Holladay SD, Xiao S, Diao H, Barber J, Nagy T, Ye X, Gogal RM Jr. Perinatal bisphenol A exposure in C57BL6/129svj male mice: Potential altered cytokine/chemokine production in adulthood. Int. J. Environ. Res. Public Health 2010 7:2845-2852.

DIAGNOSTIC LABORATORY ANIMAL PATHOLOGY

Alworth L and Nagy T. Peri-urethral swelling in a female C3H/HeNCrMTV mouse. Lab Anim (NY). 38(5):147, 2009.


Selected Publications

  • ​Poovassery JS, Sarr D, Smith G, Nagy T, Moore JM. Malaria-induced murine pregnancy failure: distinct roles for IFN-gamma and TNF. J Immunol. 2009 183(8):5342-9.
  • Alworth L and Nagy T. Peri-urethral swelling in a female C3H/HeNCrMTV mouse. Lab Anim (NY). 38(5):147, 2009.
  • Luo M, Fan H, Nagy T, Wei H, Wang C, Liu S, Wicha MS, and Guan J-L. Mammary epithelial-specific ablation of the focal adhesion kinase suppresses tumorigenesis and metastasis by affecting mammary cancer stem/progenitor cells. Cancer Res. 2009 69(2):466-74.
  • Nagy T, Wei H, Shen TL, Peng X, Liang CC, Gan B, Guan JL. Mammary Epithelial-specific Deletion of the Focal Adhesion Kinase Gene Leads to Severe Lobulo-Alveolar Hypoplasia and Secretory Immaturity of the Murine Mammary Gland. J Biol Chem. 2007 Oct 26;282(43):31766-76. Epub 2007 Aug 23.
  • Gan B, Peng X, Nagy T, Alcaraz A, Gu H, Guan JL. Role of FIP200 in cardiac and liver development and its regulation of TNFalpha and TSC-mTOR signaling pathways. J Cell Biol. 2006 Oct 9;175(1):121-33. Epub 2006 Oct 2.
  • Peng X, Ueda H, Zhou H, Stokol T, Shen TL, Alcaraz A, Nagy T, Vassalli JD, Guan JL. Overexpression of focal adhesion kinase in vascular endothelial cells promotes angiogenesis in transgenic mice. Cardiovasc Res. 2004 Dec 1;64(3):421-30.
  • Additional publications by Dr. Nagy may be found at PubMed.

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