Comparative Pathology Laboratory
The Comparative Pathology Laboratory at the University of Georgia is a full-service laboratory providing services in the area of laboratory animal pathology and research pathology. These services are available to researchers regardless of affiliation (academic, governmental, or commercial). Interested individuals are encouraged to contact us to discuss their research needs
The Comparative Pathology Laboratory is seeking collaborators engaged in new areas of research using various laboratory animal species. These new areas include—but are not limited to—drug development, novel drug delivery technologies, and translational research. Please contact us to explore possible areas of collaboration.
- Cell Constructs, Inc. (CCI) - Novel drug delivery systems using microspheres
- List of services [pdf]
- Immunohistochemical stains for infectious agents [pdf]
- Immunohistochemical stains for tumor markers [pdf]
- Histochemical special stains [pdf]
- Clinical pathology tests [pdf]
- Normal rat, mouse, and dog tissues available [pdf]
The Comparative Pathology Laboratory recently formed a working collaboration with the Transgenic Mouse & Gene Targeting Core at Emory University. Within this reciprocal partnership, the Transgenic Mouse & Gene Targeting Core at Emory will recommend the Comparative Pathology Laboratory at UGA for phenotyping services. This recommendation is not binding; however, investigators are free to use either laboratory independently.
Laboratory Animal Pathology Services
- Autopsy (Necropsy) of Research Animals
- Standard Phenotyping of Genetically Engineered Mice
- Clinical Pathology (Hematology, Cytology, Bone Marrow Evaluation, Urinalysis, etc.)
- Imaging (Radiography, Ultrasound, MRI)
- Research Collaboration and Consultation
- Preparation of Letter of Collaboration and Budget for Laboratory Animal Pathology Portion of Grant Proposals
- Expertise in Various Other Disciplines (Endocrinology, Neurology, Ophthalmology, Radiology, etc.) are also available through the College of Veterinary Medicine
Our Commitment to You
- Timeline: 7-21 business days for routine submissions
- Electronic reporting of findings, evaluation, and interpretation
- Publication quality digital images with caption and legend
Why You Need Veterinary Pathology Services
Proper interpretation of morphological changes
- Specialized training is required to recognize disease-associated abnormalities (lesions) in organs and tissues
- Assessment, description, and interpretation of specimens (lesions) should be performed by a pathologist
- Due to species differences, human vs. laboratory animal, tissues from research animals should be evaluated by a veterinary pathologist experienced in laboratory animal pathology
Expertise in animal models for specific disease
- Choosing an appropriate animal model system
- Knowing the drawbacks/limitations of the chosen animal model system (especially strain-specific pathology that can interfere with morphologic evaluation)
- Assistance in developing and validating new (especially genetically modified) models
Expertise in genetically engineered mice
- Various mouse strain(s) used to generate mutant mice usually have a unique set of background lesions
- Type of modification: transgenic, knock-out, knock-in, etc.
- Construct used can present its own set of problems: tissue-specificity of a given promoter, integration into the genome, copy number, etc.
More competitive grant applications
- Assistance with appropriate sections of grant proposals
Comparative Pathology Laboratory
Department of Pathology
501 DW Brooks Drive
Athens, GA 30602-7388
General shipping guidelines
Live research animals
Please contact us to arrange shipment of live animals.
Each fresh tissue should be placed in a leak-proof plastic container (preferably a screw-top container) and maintained at refrigerator temperatures from collection to receipt at the laboratory.
Tissues for histopathological examination
Samples should be fixed in adequate amount (i.e. 10-20 times volume of fixative to volume of tissues) of 10% neutral buffered formalin prior to shipment and should be submitted in a wide-mouth, leak-proof container. Samples need not to be refrigerated.
Packaging and labeling of diagnostic specimens are governed by applicable federal regulations. Packaging should be adequate as to prevent leakage or breakage as shippers may face prosecution if spillage and damage to mail, equipment, or personnel occurs during shipment (even if the material involved is not infectious or hazardous). The shipping container should be appropriately labeled (i.e., “Perishable, Biologic Specimen”, etc.) on the outside.