Dr. Anne-Gaelle Bebin Blackwell received her PhD in 2009 in Immunology, from the French university of Limoges studying B cells development in the mouse and the role of enhancer in class switching and immunoglobulin expression on B cells. She went on to Montana State University in Bozeman, MT as a postdoctoral researcher , where she focused on the interaction between the category B pathogen Coxiella burnetii and its infection of macrophages, concentrating on the role of TLRs in the infection of the lungs. She worked with Prof. R. Sekaly at the Vaccine and Gene Therapy Institute in Florida developing vaccine to stimulate latent CD4 T cell in AIDS patients before joining Prof. Ted Ross’ Laboratory first at the Vaccine Gene Therapy Institute and then at University of Georgia, developing and improving vaccine against Influenza virus.
Neuraminidase is the second most important glycoprotein on the surface of Influenza A virus. Interestingly, however, its presence in influenza vaccines is neither required, nor controlled. My goal in Dr. Ted Ross’s lab is to study and develop a neuraminidase supplement to the vaccine. I am currently developing a neuraminidase hybrid based on computationally optimized methods and assessing efficiency of neuraminidase activity by enzyme-linked lectin neuraminidase inhibition assay. As neuraminidase plays a role in influenza and bacterial co-infection leading to an increase mortality in humans, these studies prove determinant to improve efficacy of the vaccine by introducing a broad and strong response via neuraminidase antibodies
- PhD (2009), Immunology, University of Limoges, France
- MS (2005), Immunology, University of Limoges, France
- BS (2001), Molecular Biology, Florida Institute of Technology
Roles of Toll-Like Receptor 2 (TLR2), TLR4, and MyD88 during Pulmonary Coxiella burnetii Infection. Ramstead AG, Robison A, Blackwell A, Jerome M, Freedman B, Lubick KJ, Hedges JF, Jutila MA. Infect Immun. 2016 Mar 24;84(4):940-9. doi: 10.1128/IAI.00898-15. PMID: 26787722
Sequential activation and distinct functions for distal and proximal modules within the IgH 3′ regulatory region. Garot A, Marquet M, Saintamand A, Bender S, Le Noir S, Rouaud P, Carrion C, Oruc Z, Bébin AG, Moreau J, Lebrigand K, Denizot Y, Alt FW, Cogné M, Pinaud E. Proc Natl Acad Sci U S A. 2016 Feb 9;113(6):1618-23. doi: 10.1073/pnas.1514090113.
Increased B cell proliferation and reduced Ig production in DREAM transgenic mice. Savignac M, Mellström B, Bébin AG, Oliveros JC, Delpy L, Pinaud E, Naranjo JR. J Immunol. 2010 Dec 15;185(12):7527-36. doi: 10.4049/jimmunol.1000152. PMID: 21059893
In vivo redundant function of the 3′ IgH regulatory element HS3b in the mouse. Bébin AG, Carrion C, Marquet M, Cogné N, Lecardeur S, Cogné M, Pinaud E. J Immunol. 2010 Apr 1;184(7):3710-7. doi: 10.4049/jimmunol.0901978.