- Infectious Diseases
- MS (1990), University Montreal
- PhD (1994), University Montreal
Porphyromonas gingivalis is recognized as an important etiological agent in adult periodontal disease. There is growing evidence that P. gingivalis is related to other chronic and systemic diseases such as cardiovascular diseases and adverse pregnancy outcomes. P. gingivalis expresses many virulence factors such as hemagglutinins, fimbriae, lipopolysaccharides, capsular material and proteases that have been implicated in its pathogenesis. We are currently sequencing four strains of P. gingivalis. The availability of complete whole genome sequences from multiples strains of P. gingivalis will be important for comparative genomics. Such analysis will enable us to detect the gain or loss of genes including virulence genes, to compare metabolic pathways, and to provide insights into mechanisms of pathogenicity.
- Walters, S., M. Bélanger, P.H. Rodrigues, J. Whitlock, and A. Progulske-Fox. A member of the aa peptidase M48 superfamily of Porphyromonas gingivalis is associated with virulence in vitro and in vivo. In Press. J. Oral Microbiol.
- Abranches, J., L. Zeng, M. Bélanger, P.H. Rodrigues, P.J. Simpson-Haidaris, D. Akin, W.A. Jr. Dunn, A. Progulske-Fox, and R.A. Burne. 2009. Invasion of human coronaryartery endothelial cells by Streptococcus mutans OMZ175. Oral Microbiol. Immunol. 24:141-145.
- Walters, S., P. Rodrigues, M. Bélanger, J. Whitlock, and A. Progulske-Fox. 2009. Analysis of a Band 7/MEC-2 Family Gene of Porphyromonas gingivalis. J. Dental Res. 88:34-38.
- Dietrich, D.E., X. Xiao, D.V. Dawson, M. Bélanger, H. Xie, A. Progulske-Fox, and K.A. Brogden. 2008. Human a- and b-defensins bind to immobilized adhesins from Porphyromonas gingivalis. Infect. Immun. 76:5714-5720.
- Pingel, L.C., K.G. Kohlgraf, C.J. Hansen, , C.G. Eastman, D.E. Dietrich, K.K. Burnell, R.N. Srikantha, X. Xiao, M. Bélanger, A. Progulske-Fox, J.E. Cavanaugh, J.M. Guthmiller, G.K. Johnson, S.A. Joly, Z.B. Kurago, D.V. Dawson, and K.A. Brogden. 2008. Human b-defensin 3 binds to hemagglutinin B (rHagB), a non-fimbrial adhesin from Porphyromonas gingivalis, and attenuates a pro-inflammatory cytokine response. Immunol. Cell Biol. 86:643-649.