Labs

Pathology – Dr. Brown’s Lab

The overall mission of our lab is to explore pathogenesis of infectious diseases, using various pathologic techniques

Techniques Used in Our Laboratory


Immunohistochemistry

For finding a specific antigen within a histologic section. Here is an example. This is a section of brain from a guinea pig infected with Nipah virus. Using an antibody specific for Nipah virus, it is possible to see exactly what cells are infected (Nipah appears as the red dots).

In Situ Hybridization

For finding a specific segment of nucleic acid within a histologic section. Below is an example. Using a labeled segment of RNA that corresponds exactly to part of the genome of Newcastle disease, the virus can be seen to be replicating in Purkinje cells of the cerebellum (blue-black staining).

PCR from histologic sections