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Physiology and Pharmacology

Shiyou Chen

DVM, PhD
Professor
Email: .(JavaScript must be enabled to view this email address)


Educational Background

  • ​DVM (1988) Huazhong Agricultural University
  • PhD (1993) Nanjing Agricultural University

Teaching Experience

  • ​Mammalian Physiology (VPHY 6090, VPHY6100)
  • Cell Physiology (VPHY 8010)

Research Interests

  • ​Vascular smooth muscle differentiation and proliferation
  • Myofibroblast activation
  • Epithelial-mesenchymal transition (EMT)
  • Vascular remodeling and inflammation
  • Myocardial infarction and fibrosis
  • Transforming growth factor-β signaling and function

Selected Publications

  1. Jia Fei, Xiao-Bing Cui, Jia-Ning Wang, Kun Dong, and Shiyou Chen, ADAR1-mediated RNA editing, A novel mechanism controlling phenotypic modulation of vascular smooth muscle cells, Circulation Research, 119:463-469, 2016 (Accompanying Editorial: Circulation Research, 119:401-403, 2016)
  2. Zheng Wang, Chunyu Zeng, Van Anthony M. Villar, Shiyou Chen, Prasad Konkalmatt, Xiaoyan Wang, Laureano D. Asico, John E. Jones, Yu Yang, Hironobu Sanada, Robin A. Felder, Gilbert M. Eisner, Matthew R. Weir, Ines Armando, Pedro A. Jose, Human GRK4γ142V Variant Promotes Angiotensin II Type I Receptor–Mediated Hypertension via Renal Histone Deacetylase Type 1 Inhibition, Hypertension, 67(2):325-34, 2016
  3. Xia Guo, Xiao-Bing Cui, Jia-Ning Wang, Ning Shi, Yoshinori Fukui, Shiyou Chen, Dedicator of cytokinesis 2, a novel regulator for vascular smooth muscle phenotype and vascular remodeling, Circulation Research, 116: e71-e80, 2015;
  4. Xiaobing Cui, Junna Luan, Shiyou Chen, RGC-32 deficiency protects against hepatic steatosis by reducing lipogenesis, Journal of Biological Chemistry (JBC), 290(33):20387-95, 2015
  5. Ning Shi, Xia Guo, Shiyou Chen, Olfactomedin 2, a novel regulator for transforming growth factor-β-induced smooth muscle differentiation of human embryonic stem cell-derived mesenchymal cells, Molecular Biology of Cell, 25 (25): 4106-14, 2014
  6. Rui Tang, Gui Zhang, Shiyou Chen, RGC-32 promoted macrophage phagocytosis via direct activation of PKC pathway, Journal of Biological Chemistry (JBC), 289, 22715-22722, 2014
  7. Ning Shi and Shiyou Chen, Cell division cycle 7 mediates transforming growth factor-β-induced smooth muscle maturation, Journal of Biological Chemistry (JBC), 288(48):34336-42, 2013
  8. Weibing Xie, Zuguo Li, Ning Shi, Xia Guo, Junming Tang, Wenjun Ju, Jun Han, Tengfei Liu, Yang Chai, Erwin P Bottinger, Pedro A Jose, Shiyou Chen, Smad2 and MRTFB cooperatively regulate vascular smooth muscle differentiation from neural crest cells, Circulation Research, 113(8):e76-86, 2013 (Accompanying Editorial: Circulation Research 113: 946-948, 2013)
  9. Rui Tang, Xiao-Bing Cui, Jia-Ning Wang and Shiyou Chen, CTP synthase, a smooth muscle-sensitive therapeutic target for effective vascular repair, Arteriosclerosis, Thrombosis, and Vascular Biology (ATVB), 33(10):2336-44, 2013 (Accompanying Editorial: ATVB 33(10):2286-7, 2013, AHA news: http://newsroom.heart.org/news/new-coating-may-reduce-blood-clot-risk-inside-stents).
  10. Xiao-Bing Cui, Xia Guo and Shiyou Chen, Response gene to complement 32-deficiency causes impaired placental angiogenesis in mice, Cardiovascular Research, 99(4):632-9, 2013
  11. Xia Guo, Steven L Stice, Nolan L. Boyd and Shiyou Chen, A novel in vitro model system for smooth muscle differentiation from human embryonic mesenchymal stem cells, American Journal of Physiology-Cell Physiology, 304(4):C289-98, 2013
  12. Ning Shi, Weibing Xie, Shiyou Chen, Cell division cycle 7 is essential for the initiation of transforming growth factor-β-induced smooth muscle differentiation, Journal of Biological Chemistry (JBC), 287(9):6860–6867, 2012
  13. Jia-Ning Wang, Ning Shi, Shiyou Chen, Manganese superoxide dismutase inhibits neointima formation through attenuation of migration and proliferation of vascular smooth muscle cells, Free Radical Biology and Medicine, 52(1):173-81, 2012
  14. Weibing Xie, Zuguo Li, Xiaochun Long, Joseph M Miano, Shiyou Chen, Smad3-mediated myocardin silencing, a novel mechanism governing the initiation of smooth muscle differentiation, Journal of Biological Chemistry (JBC), 286(17):15050-7, 2011
  15. Jianing Wang, Ning Shi, Shiyou Chen, Response gene to complement 32 promotes vascular lesion formation through stimulation of smooth muscle cell proliferation and migration, Arteriosclerosis, Thrombosis, and Vascular Biology (ATVB), 31(8):e19-26, 2011
  16. Wenyan Huang, Zuguo Li, Horea Rus, Xiaoyan Wang, Pedro A Jose, Shiyou Chen, Response gene to complement 32 mediates transforming growth factor beta-induced epithelial-mesenchymal transition in human renal proximal tubular cells, Journal of Biological Chemistry (JBC), 284(14):9426-32, 2009
  17. Fengmin Li, Zaiming Luo, Wenyan Huang, Quansheng Lu, Christopher S Wilcox, Pedro A Jose and Shiyou Chen, Respose gene to complement 32, a novel regulator for transforming growth factor-beta-induced smooth muscle differentiation of neural crest cells, Journal of Biological Chemistry (JBC), 282(14):10133-7, 2007
  18. Shiyou Chen, Michelle Crawford, Regina M. Day, Victorino R. Briones, Jennifer E. Leader, Pedro A. Jose and Robert J. Lechleider, RhoA modulates Smad signaling during TGF-beta-induced smooth muscle differentiation, Journal of Biological Chemistry (JBC), 281(3):1765-70, 2006
  19. Shiyou Chen and Robert J. Lechleider, Transforming growth factor-beta-induced differentiation of smooth muscle from a neural crest cell line, Circulation Research, 94: 1195-1202, 2004
  20. Shiyou Chen, Magdalena Kulik and Robert J. Lechleider, Smad proteins mediate trancription of smooth muscle marker gene SM22alpha, Nucleic Acid Research, 31(4): 1302-10, 2003

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