University of Georgia
  1. Zhao JY, Chen YX, Zhi LT, Xu Q, Zhang H*, Li CJ* (2024) Loss of PINK1 causes age-dependent mitochondrial trafficking deficits in nigrostriatal dopaminergic neurons through aberrant activation of p38 MAPK. BioRxiv 2024.07.17. 602426 https://doi.org/10.1101/2024.07.17.602426
  2. Msackyi M, Chen YX, Tsering WC, Wang NH, and Zhang H* (2024) Dopamine release neuroenergetics in mouse striatal slice.  Int J Mol Sci, Apr 23;25(9):4580. doi: 10.3390/ijms25094580. PMID: 38731799
  3. Zhi LT, Zhao JY, Jaffe D, Chen YX, Wang NH, Qin Q, Seifert EL, Li CJ, and Zhang H* (2022) Seahorse measurement of oxygen consumption rate (OCR) in acute striatal slices from adult mice. J Vis Exp 2022 Jun 8;(184). doi: 10.3791/63379 PMID: 35758711
  4. Crittenden JR, Zhai S, Sauvage M, Kitsukawa T, Burguière E, Thomsen M, Zhang H, Costa C, Martella G, Ghiglieri V, Picconi B, Pescatore KA, Unterwald EM, Jackson WS, Housman DE, Caine SB, Sulzer D, Calabresi P, Smith AC, Surmeier DJ, and Graybiel AM (2021) CalDAG-GEFI mediates striatal cholinergic modulation of dendritic excitability, synaptic plasticity and psychomotor behaviors. Neurobiol Dis. 2021 Aug 8;158:105473. doi: 10.1016/j.nbd.2021.105473. PMID: 3437114
  5. Shani V, Safory H, Szargel R, Wang NH, Cohen T, Elghani FA, Hamza H, Savyon M, Radzishevsky I, Shaulov L, Rott R, Lim KL, Ross CA, Bandopadhyay R, Zhang H, and Engelender S (2019) Physiological and pathological roles of LRRK2 in the nuclear envelope integrity. Hum Mol Genet. 2019 Dec 1;28(23):3982-3996. doi: 10.1093/hmg/ddz245.
  6. Singh A, Zhi L, and Zhang H* (2019) LRRK2 and mitochondria: Recent advances and current views. Brain Res. 2019 Jan 1;1702:96-104. doi: 10.1016/j.brainres.2018.06.010. Epub 2018 Jun 9. Review
  7. Schaffner A, Li X, Gomez-Llorente Y, Leandrou E, Memou A, Clemente N, Yao C, Afsari F, Zhi L, Pan N, Morohashi K, Hua X, Zhou MM, Wang C, Zhang H, Chen SG, Elliott CJ, Rideout H, Ubarretxena-Belandia I, and Yue Z (2019). Vitamin B12 modulates Parkinson’s disease LRRK2 kinase activity through allosteric regulation and confers neuroprotection. Cell Res. 29(4):313-329. doi: 10.1038/s41422-019-0153-8
  8. Zhi LT, Qin Q, Muqeem T, Seifert E, Liu W, Zheng SH, Li C, and Zhang H* (2019) Loss of PINK1 causes age-dependent decreased dopamine release in the dorsal striatal slices. Neurobiol Aging. 75:1-10. doi:10.1016/j.neurobiolaging.2018.10.025. Epub 2018 Nov 2.
  9. Choi SJ, Mukai J, Kvajo M, Xu B, Diamantopoulou A, Pitychoutis, PM, Gou B, Gogos JA, and Zhang H* (2017) A schizophrenia-related deletion leads to KCNQ2-depended abnormal dopaminergic modulation of prefrontal cortex interneuron activity. Cereb Cortex 28:2175-2191, Epub 2017 May 19. doi: 10.1093/cercor/bhx123.
  10. Qin Q, Zhi LT, Li XT, Yue ZY, Li GZ, and Zhang H* (2016) Effects of LRRK2 Inhibitors on Nigrostriatal Dopaminergic Neurotransmission. CNS Neurosci Ther. doi: 10.1111/cns.12660.
  11. Divito CB, Steece-Collier K, Case DT, Williams SP, Stancati JA, Zhi L, Rubio ME, Sortwell CE, Collier TJ, Sulzer D, Edwards RH, Zhang H, and Seal RP (2015) Loss of VGLUT3 produces hyperdopaminergia and ameliorates motor dysfunction and L-dopa mediated dyskinesias in a model of Parkinson’s disease. J. Neurosci 35:14983-99.
  12. Rodriguez PC, Pereira DB, Borgkvist A, Wong MY, Barnard C, Sonders MS, Zhang H, Sames D, and Sulzer D (2013) Fluorescent dopamine tracer resolves individual dopaminergic synapses and their activity in the brain. PNAS 110: 870-5.
  13. Zhang H*, and Sulzer D (2012) Regulation of striatal dopamine release by presynaptic auto- and heteroreceptors. Basal Ganglia 2: 5-13. Review
  14. Hnasko TS, Chuhma N, Zhang H, Goh G, Sulzer D, Palmiter RD, Rayport S, and Edwards RH (2010) Vesicular glutamate transport promotes dopamine storage and glutamate corelease in vivo. Neuron. 65: 643-56.
  15. Zhang H*, Gubernator NG, Yue M, Staal RG, Mosharov EV, Pereira D, Balsanek V, Vadola PA, Mukherjee B, Edwards RH, Sulzer D, and Sames D (2009) Dopamine release at individual presynaptic terminals visualized with FFNs. J Vis Exp. pii: 1562. doi: 10.3791/1562
  16. Gubernator NG, Zhang H (co-first author), Mosharov,EV, Staal RG, Balsanek V, Cadola PA, Wallender E, Edwards RH, Sulzer D, and Sames D (2009) Fluorescent false neurotransmitters visualize dopamine release from individual presynaptic terminals. Science 324:1441-4.
  17. Bamford NS, Zhang H, Joyce JA, Scarlis CA, Harleton E, and Sulzer D (2008) Chronic methamphetamine induces reversible long-term presynaptic depression at corticostriatal terminals. Neuron 58:89-103. Please also see Comment on this research in Neuron 2008, 58: 6-7 and in Nature Reviews Neurosci, 2008.
  18. Paterlini M, Zakharenko SS, Lai WS, Qin J, Zhang H, Mukai J, Westphal KG, Olivier B, Sulzer D, Pavlidis P, Siegelbaum SA, Karayiorgou M, and Gogos JA (2005) Transcriptional and behavioral interaction between 22S, Zhang H, Schmitz Y, Wu NP, Cepeda C, Levine MS, Schmauss C, Zakharenko SS, Zablow L, and Sulzer D (2004) Heterosynaptic dopamine neurotransmission selects sets of corticostriatal terminals. Neuron 42: 653-63.
  19. Son JH, Kawamata H, Yoo MS, Kim DJ, Lee YK, Kim S, Dawson TM, Zhang H, Sulzer D, Yang L, Beal MF, Degiorgio LA, Chun HS, Baker H, and Peng C (2005) Neurotoxicity and behavioral deficits associated with Septin 5 accumulation in dopaminergic neurons. J Neurochem 94: 1040-53.
  20. Zhang H, and Sulzer D (2004) Frequency-dependent modulation of dopamine release by nicotine. Nat Neurosci 7: 581-2.
  21. Bamford NS, Zhang H, Schmitz Y, Wu NP, Cepeda C, Levine MS, Schmauss C, Zakharenko SS, Zablow L, and Sulzer D (2004) Heterosynaptic dopamine neurotransmission selects sets of corticostriatal terminals. Neuron 42: 653-63.
  22. Kholodilov N, Yarygina O, Oo TF, Zhang H, Sulzer D, Dauer W, and Burke RE (2004) Regulation of the development of mesencephalic dopaminergic systems by the selective expression of glial cell line-derived neurotrophic factor in their targets. J Neurosci 24: 3136-46.
  23. Chuhma N, Zhang H, Masson J, Zhuang X, Sulzer D, Hen R, and Rayport S (2004) Dopamine neurons mediate a fast excitatory signal via their glutamatergic synapses. J Neurosci 24: 972-81.
  24. Zhang H, and Sulzer D (2003) Glutamate spillover in the striatum depresses dopaminergic transmission by activating group I metabotropic glutamate receptors. J Neurosci 23: 10585-92.
  25. Venton BJ, Zhang H, Garris PA, Phillips PE, Sulzer D, and Wightman RM (2003) Real-time decoding of dopamine concentration changes in the caudate-putamen during tonic and phasic firing. J Neurochem 87: 1284-95.
  26. Fremeau RT Jr, Burman J, Qureshi T, Tran CH, Proctor J, Johnson J, Zhang H, Sulzer D, Copenhagen DR, Storm-Mathisen J, Reimer RJ, Chaudhry FA, and Edwards RH (2002) The identification of vesicular glutamate transporter 3 suggests novel modes of signaling by glutamate. PNAS 99: 14488-93
  27. Zhang H, and Karlin A (1998) Contribution of the β subunit M2 segment to the ion-conducting pathway of the acetylcholine receptor. Biochemistry 37: 7952-64.
  28. Zhang H, and Karlin A (1997) Identification of acetylcholine receptor channel-lining residues in the M1 segment of the β subunit. Biochemistry 36: 15856-64.q11.2 orthologs modulates schizophrenia-related phenotypes in mice. Nat Neurosci 8:1586-94.

going beyond the expected