Department of Pathology, Precision One Health
Director - Precision One Health Initiative, Professor of Systems Pharmacology, Wynocker Professor for Advancing Canine Kidney Disease Research
Biography
Dr. Jon P. Mochel is a Professor of Systems Pharmacology in the Department of Pathology and the Founding Director of the Precision One Health Initiative at the University of Georgia (UGA). He has an extensive background in clinical and basic pharmacology and toxicology and is a board-certified veterinary pharmacologist and toxicologist (DECVPT). Dr. Mochel holds advanced degrees in pharmacology (MS), pharmacokinetics (MS), and applied mathematical modeling (PhD), with his research focusing on the effects of therapeutic drugs in complex biological systems, including the heart and kidneys.
Dr. Mochel is a Fellow of the American Academy of Veterinary Pharmacology and Therapeutics and serves as an ad hoc reviewer for several prestigious organizations, including the US National Science Foundation, the National Institute of Standards and Technology, the UK Medical Research Council, and the CNRS/INSERM ATIP-Avenir Program. His contributions have earned him the Early Career (2019) and Mid-Career Achievement (2022) Research Awards from Iowa State University’s College of Veterinary Medicine, as well as the American Academy of Veterinary Pharmacology Research Award (2022).
Currently, Dr. Mochel serves as President of the Animal Health Modeling and Simulation Society and the European Association of Veterinary Pharmacology and Toxicology. He has authored over 150 peer-reviewed publications in leading biomedical journals and has secured more than $16 million in research funding as a principal investigator or co-investigator over the past seven years. As of 2024, Dr. Mochel is recognized among Stanford University’s list of the “World’s Top 2% scientists.”
Selected Publications
REVIEWS AND COMMENTARIES
Wiley HS, Lopez CF, Rodin AS, Rockne RC, Yankeelov TE, Sauro HM, Hassan G, Prabhakaran S, Demir E, Hu M, Fuxman Bass J, Luddy KA, Newman H, Mochel JP, Costello JC, Xing J, Afify SM, Acar A, Hayden Gephart M, Feng S, Banks O, Banerjee J, Clayton A, Hill DE, Sweis RF, Umeh-Garcia MC, Su Y, Meyer AS. A Roadmap for the Future of Systems Biology in Cancer Research. Cancer Res. 2025 Oct 15. DOI: 10.1158/0008-5472.CAN-25-0700. PMID: 41091803.
Nolan LK, Allenspach K, Mochel JP, Zavros Y, Carter AH. Interdisciplinary Research Seeks Treatments and Cures for Diseases of Animals and Humans. Am J Vet Res. 2025 Sep 4:1.DOI: 10.2460/ajvr.25.07.0274. PMID: 40907567.
Martinez MN#, Mochel JP#*, Toutain PL#. Evolving Value and Validity of Animal Models in Veterinary Therapeutic Research: Impact of Scientific Progress. Eur J Pharm Sci. 2025 Apr 24:107111. DOI: 10.1016/j.ejps.2025.107111. PMID: 40286991. #Equal contribution, *: corresponding author.
Quisenberry S, Allenspach-Jorn K, Mochel J, Nolan LK, Carter AH. University of Georgia College of Veterinary Medicine’s Precision One Health Initiative Improves Animal and Human Health by Developing Alternative Models of Disease. Am J Vet Res. 2024 Sep 9:1. DOI: 10.2460/ajvr.24.07.0212. PMID: 39250932.
Allenspach K, Zavros Y, Elbadawy M, Zdyrski C, Mochel JP. Leveraging the Predictive Power of 3D Organoids in Dogs to Develop New Treatments for Man and Man’s Best Friend. BMC Biol. 2023 Dec 29;21(1):297. doi: 10.1186/s12915-023-01799-5. PMCID: PMC10755934.
Gabriel V, Zdyrski C, Sahoo DK, Ralston A, Wickham H, Bourgois-Mochel A, Ahmed B, Merodio MM, Paukner K, Piñeyro P, Kopper J, Rowe EW, Smith JD, Meyerholz D, Kol A, Viall A, Elbadawy M, Mochel JP, Allenspach K. Adult Animal Stem Cell-Derived Organoids in Biomedical Research and the One Health Paradigm. Int J Mol Sci. 2024 Jan 5;25(2):701. doi: 10.3390/ijms25020701. PMCID: PMC10815683.
Gehring R, Mochel JP, Schmerold I. Understanding the Background and Clinical Significance of the WHO, WOAH, and EMA Classifications of Antimicrobials to Mitigate Antimicrobial Resistance. Front Vet Sci. 2023 Mar 17;10:1153048. DOI: 10.3389/fvets.2023.1153048. PMCID: PMC10063873.
Ahmed BH, Zdyrski C, Cheville J, Rancilio N, Abel AM, Wierson WA, McGill JL, Mochel JP, Allenspach K. Role of the Tumor Microenvironment in Bladder Cancer Pathogenesis and Value of the Reverse Translational Approach: A Tale of Two Species. Clin Transl Discov. 2023 Aug 8. DOI: 10.1002/ctd2.235.
Martinez M, Mochel JP*, Neuhoff S*, Pade D*. Comparison of Canine and Human Physiological Factors:Understanding Interspecies Differences that Impact Drug Pharmacokinetics. 2021. AAPS J. 2021 Apr 27;23(3):59. DOI: 10.1208/s12248-021-00590-0. PMID: 33907906. *: equal contributions.
Kopper JJ, Iennarella-Servantez C, Jergens AE, Sahoo DK, Guillot E, Bourgois-Mochel A, Martinez MN, Allenspach K, Mochel JP. Harnessing the Biology of Canine Intestinal Organoids to Heighten Understanding of Inflammatory Bowel Disease Pathogenesis and Accelerate Drug Discovery: A One Health Approach. Front Toxicol. 2021 Nov 10;3:773953. DOI: 10.3389/ftox.2021.773953. PMCID: PMC8915821.
Allenspach K, Mochel JP. Current Diagnostics for Chronic Enteropathies in Dogs. Vet Clin Pathol. 2021 Oct 26. DOI: 10.1111/vcp.13068. PMID: 34699081.
Minkler S, Lucien F, Kimber MJ, Sahoo DK, Bourgois-Mochel A, Musser M, Johannes C, Frank I, Cheville J, Allenspach K, Mochel JP. Emerging Roles of Urine-Derived Components for the Management of Bladder Cancer: One Man’s Trash Is Another Man’s Treasure. Cancers (Basel). 2021 Jan 23;13(3):422. DOI: 10.3390/cancers13030422. PMID: 33498666.
Sebbag L, Mochel JP. An Eye on the Dog as the Scientist’s Best Friend for Translational Research in Ophthalmology:A Focus on the Ocular Surface. Med Res Rev. 2020 Nov;40(6):2566-2604. DOI: 10.1002/med.21716. PMID: 32735080.
Martinez M, Mochel JP*, Pade D*. Pharmacokinetic Considerations In Inter-Species Comparisons. Curr Opin Toxicol.2020 Oct 23:98-105. *: equal contributions.
Ambrosini YM, Borcherding D, Kanthasamy A, Kim HJ, Willette AA, Jergens A, Allenspach K, Mochel JP. The Gut-Brain Axis in Neurodegenerative Diseases and Relevance of the Canine Model: A Review. Front Aging Neurosci. 2019 Jun 18;11:130. DOI: 10.3389/fnagi.2019.00130. eCollection 2019. PMCID: PMC6591269. Chief Editor’s Top Pick 2019-21.
Mochel JP, Ekker SC, Johannes CM, Jergens AE, Allenspach K, Bourgois-Mochel A, Knouse M, Benzekry S, Wierson W, LeBlanc AK, Kenderian S. CAR T-Cell Immunotherapy in Human and Veterinary Oncology: Changing the Oddsagainst Hematological Malignancies. AAPS J. 2019 Apr 8;21(3):50. DOI: 10.1208/s12248-019-0322-1. PMID:30963322.
Martinez M, Boopathy S*, Carlert S*, Jamei M*, Mochel JP* and Vertzoni M*. Workshop Report: USP Workshop onExploring the Science of Drug Absorption. Dissol Technol. 2019. DOI: 10.14227/DT260319P38. *: equal contributions.
Martinez MN*, Gehring R*, Mochel JP*, Pade D*, Pelligand L*. Population Variability in Animal Health: Influence on Dose-Exposure-Response Relationships: Part II: Modelling and Simulation. J Vet Pharmacol Ther. 2018 Aug;41(4):E68-E76. DOI: 10.1111/jvp.12666. PMID: 29806231. *: equal contributions.
Mochel JP, Tyden E, Hellmann K, Vendrig JC, Şenel S, Dencker L, Cristina RT, Linden H, Schmerold I. Network onVeterinary Medicines Initiated by the European Federation For Pharmaceutical Sciences. J Vet Pharmacol Ther. 2018Jun;41(3):378-383. DOI: 10.1111/jvp.12472. PMID: 29266320.
Bon C, Toutain PL, Concordet D, Gehring R, Martin-Jimenez T, Smith J, Pelligand L, Martinez M, Whittem T, Riviere JE,Mochel JP. Mathematical Modeling and Simulation in Animal Health. Part III: Using Nonlinear Mixed-Effects to Characterize and Quantify Variability in Drug Pharmacokinetics. J Vet Pharmacol Ther. 2018 Apr;41(2):171-183. DOI:10.1111/jvp.12473. PMID: 29226975.
Schneider B, Balbas-Martinez V, Jergens AE, Troconiz IF, Allenspach K, Mochel JP. Model- Based Reverse TranslationBetween Veterinary and Human Medicine: The One Health Initiative. CPT Pharmacometrics Syst Pharmacol. 2018 Feb;7(2):65-68. DOI: 10.1002/psp4.12262. PMID: 29178333.
Mochel JP, Jergens AE, Kingsbury D, Kim HJ, Martín MG, Allenspach K. Intestinal Stem Cells to Advance Drug Development, Precision, and Regenerative Medicine: A Paradigm Shift in Translational Research. AAPS J. 2017 Dec 12;20(1):17. DOI: 10.1208/s12248-017-0178-1. Review. PMID: 29234895.
Lin Z, Gehring R, Mochel JP, Lavé T, Riviere JE. Mathematical Modeling and Simulation in Animal Health – Part II: Principles, Methods, Applications, and Value of Physiologically Based Pharmacokinetic Modeling in Veterinary Medicineand Food Safety Assessment. J Vet Pharmacol Ther. 2016 Oct;39(5):421-38. DOI: 10.1111/jvp.12311. PMID: 27086878.
Dencker L*, Hellmann K*, Mochel J*, Senel S*, Linden H*, Tyden E*, Vendrig JC*, Schmerold I. EUFEPS Network on Veterinary Medicines Initiative: An Interdisciplinary Forum to Support Veterinary Pharmacology and Promote the Development of New Pharmaceuticals for Animal Health. Eur J Pharm Sci. 2016 August 25; 91:I- VII. DOI:10.1016/s0928-0987(16)30254-8. *: equal contributions.
Riviere JE, Gabrielsson J, Fink M, Mochel J. Mathematical Modeling and Simulation in Animal Health. Part I: Moving Beyond pharmacokinetics. J Vet Pharmacol Ther. 2016 Jun;39(3):213-23. DOI: 10.1111/jvp.12278. PMID: 26592724.
Mochel JP, Gabrielsson J, Collard W, Fink M, Gehring R, Laffont C, Liu Y, Martin-Jimenez T, Pelligand L, Steimer JL, Toutain PL, Whittem T, Riviere J. Animal Health Modeling & Simulation Society: A New Society Promoting Model-Based Approaches in Veterinary Pharmacology. J Vet Pharmacol Ther. 2013 May 29. DOI: 10.1111/jvp.12060. PMID:23713757.
LETTERS
Woodward AP, Mochel JP. Letter Regarding “Recommendations for a Complete Reporting of Statistical Methods in Veterinary Pharmacology“. J Vet Pharmacol Ther. 2025 Sep;48(5):439-440. DOI: 10.1111/jvp.70018. Epub 2025 Aug 7. PMID: 40776558.
Allenspach K, Handel A, Marks S, Kook P, Simpson K, Bartges J, Fukushima K, Kathrani A, Salavati S, Dandrieux J, Mansfield C, Manchester A, Webb C, Freiche V, Billings WZ, Mochel JP. Letter Regarding “Fuzapladib in a randomized controlled multicenter masked study in dogs with presumptive acute onset pancreatitis“. J Vet Intern Med. 2024 May-Jun;38(3):1282-1284. DOI: 10.1111/jvim.17025. Epub 2024 Mar 5. PMCID: PMC11099700.
Smith J, Merkatoris P, Breuer RM, Videla R, Mulon PY, Schleining J, Nagy D, Fajt V, Reed S, Mochel JP, Kreuder A, Dowling P. Letter Regarding “Gastrointestinal Foreign Bodies in Pet Pigs: 17 cases“. J Vet Intern Med. 2022 Jul 8. DOI: 10.1111/jvim.16479. PMID: 35801825.
Atkins C, Keene B, DeFrancesco TC, Tou S, Chetboul V, Côté É, Ettinger S, Fox PR, Hamlin RL, Mochel JP, Pouchelon JL, Stepien RL. Letter to the Editor Regarding “Efficacy of Adding Ramipril (Vasotop) to the Combination of Furosemide (Lasix) and Pimobendan (Vetmedin) in Dogs with Mitral Valve Degeneration: The VALVE Trial“. J Vet Intern Med. 2021 Mar;35(2):698-699. DOI: 10.1111/jvim.16035. PMID: 33502753.
Mochel J, Fink M. Response to Letter from Atkins et al. J Vet Pharmacol Ther. 2013 Apr. DOI: 10.1111/jvp.12017.
ORIGINAL RESEARCH PAPERS
Grounded in systems pharmacology—the pharmacology of integrated biological systems—my program bridges modalities and scales to explain and predict therapeutic drug response. As such, my publication portfolio is broad by design. To build predictive, translatable models, this work spans (1) comparative pharmacology and disease modeling studies to understand drug pharmacokinetics and pharmacodynamics across species; (2) experimental platforms such as adult stem cell–derived organoids to study disease pathomechanisms and reduce animal use; and (3) clinical studies in veterinary and human populations to validate and refine model-based predictions. What may seem diverse is, in fact, a single integrated in silico–in vitro–in vivo pipeline—advancing from mechanism to clinical outcome within a One Health framework.
PHYSIOLOGY & PHARMACOLOGY
(i) Cardiometabolism. This body of work focuses on the mechanistic evaluation and quantitative modeling of cardiovascular, renal, and metabolic systems across species. Studies span the pharmacologic modulation of the renin-angiotensin-aldosterone system (RAAS), optimizing dose-response for ACE inhibitors and mineralocorticoid receptor antagonists, and characterizing the effects of glucocorticoids on cardiorenal physiology. A strong emphasis is placed on integrating pharmacokinetic-pharmacodynamic (PK/PD) modeling, chronobiology, and biomarker-based outcome prediction to support translational dosing strategies. More recent work also extends into preclinical modeling of metabolic syndrome to assess pleiotropic therapeutic effects beyond weight modulation.
Manson E, Ward JL, Merodio M, Guillot E, Blondel T, Domenig O, Mochel JP. Dose-Exposure-Response of CARDALIS® (Benazepril/Spironolactone) on the Classical and Alternative Arms of the Renin-Angiotensin-Aldosterone System in Healthy Dogs. J Vet Intern Med. 2025 Jan-Feb;39(1):e17255. DOI: 10.1111/jvim.17255. Epub 2024 Nov 27. PMCID: PMC11638133.
Mochel JP, Ward JL, Blondel T, Kundu D, Merodio MM, Zemirline C, Guillot E, Giebelhaus RT, de la Mata P, Iennarella-Servantez C, Blong A, Nam SL, Harynuk JJ, Suchodolski J, Tvarijonaviciute A, Cerón JJ, Bourgois-Mochel A, Zannad F, Sattar N, Allenspach K. Preclinical Modeling of Metabolic Syndrome to Study the Pleiotropic Effects of Novel Antidiabetic Therapy Independent of Obesity. Sci Rep. 2024 Sep 5;14(1):20665. DOI: 10.1038/s41598-024-71202-y. PMCID: PMC11377553.
Garcia Marrero TM, Ward JL, Tropf MA, Bourgois-Mochel A, Guillot E, Domenig O, Yuan L, Kundu Debosmita and Mochel JP. Effect of Amlodipine on the Circulating Renin-Angiotensin Aldosterone System in Healthy Cats. J Vet Intern Med. 2024 Feb 9. DOI: 10.1111/jvim.17006. PMID: 38334012.
Masters AK, Ward JL, Guillot E, Domenig O, Yuan L, Mochel JP. Comprehensive Characterization of the Effect of Mineralocorticoid Receptor Antagonism with Spironolactone on the Renin-Angiotensin-Aldosterone System in Healthy Dogs. PLoS One. 2024 Feb 23;19(2):e0298030. DOI: 10.1371/journal.pone.0298030. PMID: 38394253; PMCID: PMC10890738.
Schneider B, Ward J, Sotillo S, Garelli-Paar C, Guillot E, Prikazsky M, Mochel JP. Breakthrough: A First-In-Class Virtual Simulator for Dose Optimization of ACE Inhibitors in Translational Cardiovascular Medicine. Sci Rep. 2023 Feb 26;13(1):3300. DOI: 10.1038/s41598-023-30453-x. PMCID: PMC9968717.
Sotillo A, Ward JL, Guillot E, Domenig O, Yuan L, Smith JS, Gabriel V, Iennarella-Servantez A, Mochel JP. Dose-Response of Benazepril on Biomarkers of the Classical and Alternative Pathways of the Renin-Angiotensin-Aldosterone System in Dogs. Sci Rep. 2023 Feb 15;13(1):2684. DOI: 10.1038/s41598-023-29771-x. PMCID: PMC9932142.
Ward JL, Chou YY, Yuan L, Dorman K, Mochel JP. Retrospective Evaluation of a Dose-Response RelationshipBetween Angiotensin-Converting Enzyme Inhibitors and Long-Term Outcome in Dogs with Cardiac Disease. J Vet InternMed. 2021. DOI: 10.1111/jvim.16236. PMID: 34387901.
Tinklenberg RL, Murphy SD, Mochel JP, Seo YJ, Mahaffey AL, Yan Y, Ward JL. Dose-Response Effects of Oral Short-Term Prednisone Therapy on Clinicopathologic and Hemodynamic Variables in Healthy Dogs. Am J Vet Res.2020;81(4):317–325. DOI:10.2460/ajvr.81.4.317. PMID: 32228253.
Khelik IA, Berger DJ, Mochel JP, Seo YJ, Palerme JS, Ware WA, Ward JL. Clinicopathologic, Hemodynamic, and Echocardiographic Effects of Short-Term Anti-Inflammatory Glucocorticoid Treatment in Systemically Healthy Cats. AmJ Vet Res. 2019 Aug;80(8):743-755. DOI: 10.2460/ajvr.80.8.743. PMID: 31339769.
Masters AK, Berger DJ, Ware WA, Langenfeld NR, Coetzee JF, Mochel JPM, Ward JL. Effects of Short-Term Anti-Inflammatory Glucocorticoid Treatment on Clinicopathologic, Echocardiographic, and Hemodynamic Variables in Systemically Healthy Dogs. Am J Vet Res. 2018 Apr;79(4):411- 423. DOI: 10.2460/ajvr.79.4.411. PMID: 29583045.
Mochel JP, Teng CH, Peyrou M, Giraudel J, Danhof M, Rigel DF. Sacubitril/Valsartan Significantly ReducesAldosterone and Increases cGMP Circulating Levels in a Canine Model of RAAS Activation. Eur J Pharm Sci. 2018Nov;128:103-111. DOI: 10.1016/j.ejps.2018.11.037. PMID: 30508581.
Bieth B, Bornkamp B, Toutain C, Garcia R, Mochel JP. Multiple Comparison Procedure and Modeling: A Versatile Toolfor Evaluating Dose-Response Relationships in Veterinary Pharmacology – A Case Study with Furosemide. J Vet Pharmacol Ther. 2016 Dec;39(6):539-546. DOI: 10.1111/jvp.12313. PMID: 27166146.
Mochel JP, Fink M, Peyrou M, Soubret A, Giraudel JM, Danhof M. Pharmacokinetic-Pharmacodynamic Modeling of Renin-Angiotensin Aldosterone Biomarkers Following Angiotensin-Converting Enzyme (ACE) Inhibition Therapy with Benazepril in Dogs. Pharm Res. 2015 Jun;32(6):1931-46. DOI: 10.1007/s11095-014- 1587-9. PMID: 25446774.
Mochel JP, Danhof M. Chronobiology and Pharmacologic Modulation of the Renin- Angiotensin- Aldosterone System in Dogs: What Have We Learned? Rev Physiol Biochem Pharmacol. 2015;169:43-69. DOI: 10.1007/112_2015_27. PMID: 26428686.
Mochel JP, Fink M, Bon C, Peyrou M, Bieth B, Desevaux C, Deurinck M, Giraudel JM, Danhof M. Influence of Feeding Schedules on the Chronobiology of Renin Activity, Urinary Electrolytes and Blood Pressure in Dogs. Chronobiol Int. 2014 Jun;31(5):715-30. DOI: 10.3109/07420528.2014.897711. PMID: 24654920.
Mochel JP, Fink M, Peyrou M, Desevaux C, Deurinck M, Giraudel JM, Danhof M. Chronobiology of the Renin Angiotensin Aldosterone System in Dogs: Relation to Blood Pressure and Renal Physiology. Chronobiol Int. 2013 Nov;30(9):1144-59. PMID: 23931032.
Mochel JP, Peyrou M, Fink M, Strehlau G, Mohamed R, Giraudel JM, Ploeger B, Danhof M. Capturing the Dynamics of systemic Renin-Angiotensin-Aldosterone System (RAAS) Peptides Heightens the Understanding of the Effect of Benazepril in Dogs. J Vet Pharmacol Ther. 2013 Apr;36(2):174-80. DOI: 10.1111/j.1365- 2885.2012.01406.x. PMID:22568394.
(ii) Gastroenterology. These publications investigate the pathophysiology, immunology, and therapeutic modulation of chronic enteropathies and intestinal inflammation, primarily in canine models. The studies assess dietary interventions, probiotics, synbiotics, and glycosaminoglycans in shaping gut microbiota and mucosal function, with strong translational implications for human inflammatory bowel disease.
Sahoo DK, Stewart T, Lindgreen EM, Patel B, Patel A, Trivedi JN, Parker V, Rudinsky AJ, Winston JA, Bourgois-Mochel A, Mochel JP, Allenspach K, Heilmann RM, Jergens AE. Restorative Effects of Synbiotics on Colonic Ultrastructure and Oxidative Stress in Dogs with Chronic Enteropathy. Antioxidants (Basel). 2025 Jun 13;14(6):727. DOI: 10.3390/antiox14060727. PMCID: PMC12189513.
Mason B, Sahoo DK, Iennarella-Servantez CA, Morgan S, Bourgois-Mochel A, Bray A, Suchodolski JS, Ackermann MA, Mochel JP, Allenspach K, Jergens AE. Effects of a Western diet on Colonic Dysbiosis, Bile Acid Dysmetabolism and Intestinal Inflammation in Clinically Healthy Dogs. J Vet Intern Med. 2025 Mar-Apr;39(2):e70035. DOI: 10.1111/jvim.70035. PMCID: PMC11923555.
Allenspach K, Sung CH, Ceron JJ, Peres Rubio C, Bourgois-Mochel A, Suchodolski JS, Yuan L, Kundu D, Colom Comas J, Rea K, Mochel JP. Effect of the Probiotic Bacillus subtilis DE-CA9TM on Fecal Scores, Serum Oxidative Stress Markers and Fecal and Serum Metabolome in Healthy Dogs. Vet Sci. 2023 Sep 11;10(9):566. DOI: 10.3390/vetsci10090566. PMCID: PMC10537710.
Sahoo DK, Allenspach K, Mochel JP, Parker V, Rudinsky AJ, Winston JA, Bourgois-Mochel A, Ackermann M, Heilmann RM, Köller G, Yuan L, Stewart T, Morgan S, Scheunemann KR, Iennarella-Servantez CA, Gabriel V, Zdyrski C, Pilla R, Suchodolski JS, Jergens AE. Synbiotic-IgY Therapy Modulates the Mucosal Microbiome and Inflammatory Indices in Dogs with Chronic Inflammatory Enteropathy: A Randomized, Double-Blind, Placebo-Controlled Study. Vet Sci. 2022 Dec 30;10(1):25. DOI: 10.3390/vetsci10010025. PMCID: PMC9867299.
Allenspach K, Borcherding DC, Iennarella-Servantez C, Ambrosini Y, Atherly T, Bourgois-Mochel A, Rossoni M, Kilburn L, Jergens AE, Mochel JP. Ketogenic Diets in Healthy Dogs Induce Gut and Serum Metabolome Changes Suggestive of Anti-Tumourigenic Effects: A Model for Human Ketotherapy Trials. Clin Transl Med. 2022 Sep;12(9):e1047. DOI: 10.1002/ctm2.1047. PMCID: PMC9506423.
Glanemann B, Seo YJ, Priestnall S, Garden OA, Jergens AE, Segarra S, Mochel JP, Allenspach K. Clinical Efficacy of Prebiotics and Glycosaminoglycans versus Placebo In Dogs with Food Responsive Enteropathy Receiving aHydrolyzed Diet: A Pilot Study. PLoS One. 2021 Oct 21;16(10):e0250681. DOI: 10.1371/journal.pone.0250681. PMCID: PMC8530283.
Ambrosini YM, Borcherding D, Seo YJ, Segarra S, Glanemann B, Garden OA, Neuber S, Müller U, Dang V, Borts D, Atherly T, Jergens A, Mochel JP, Allenspach K. Treatment with Hydrolyzed Diet Supplemented with Prebiotics and Glycosaminoglycans Alters Lipid Metabolism in a Canine Model of Inflammatory Bowel Disease. Front Vet Sci. 2020 Jul 30;7:451. DOI: 10.3389/fvets.2020.00451. PMID: 32851029.
Atherly T, Rossi G, White R, Seo YJ, Allenspach K, Mochel JP, Jergens AE. Glucocorticoid Effects on Mucosal Bacteria in Canine Inflammatory Bowel Disease. PLoS One. 2019 Dec 30;14(12):e0226780. DOI:10.1371/journal.pone.0226780. PMID: 31887117.
Jergens AE, Guard BC, Redfern A, Rossi G, Mochel JP, Pilla R, Chandra L, Seo YJ, Steiner JM, Lidbury J, Allenspach K, Suchodolski J. Microbiota-Related Changes in Unconjugated Fecal Bile Acids Are Associated With Naturally Occurring,Insulin-Dependent Diabetes Mellitus in Dogs. Front Vet Sci. 2019 Jun 27;6:199. DOI: 10.3389/fvets.2019.00199. eCollection 2019. PMCID: PMC6610424.
Kathrani A, Lezcano V, Hall EJ, Jergens AE, Mochel JP, Atherly T, Allenspach K. Indoleamine- Pyrrole 2,3-Dioxygenase-1 (IDO-1) mRNA is Over-Expressed in the Duodenal Mucosa and is Negatively Correlated with Serum Tryptophan Concentrations in Dogs with Protein-Losing Enteropathy. PLoS One. 2019 Jun 10;14(6):e0218218. DOI: 10.1371/journal.pone.0218218. PMID: 31181125.
Kathrani A, Lezcano V, Hall EJ, Jergens AE, Seo YJ, Mochel JP, Atherly T, Allenspach K. IL-13 and IL-33 mRNA areUnder-Expressed in the Duodenal Mucosa of German Shepherd Dogs with Inflammatory Bowel Disease. J Vet Intern Med.2019 Jun 6. DOI: 10.1111/jvim.15544. PMID: 31169944.
Allenspach KA, Mochel JP, Du Y, Priestnall SL, Moore F, Slayter M, Rodrigues A, Ackermann M, Krockenberger M, Mansell J; WSAVA GI Standardization Working Group; Luckschander N, Wang C, Suchodolski J, Berghoff N, Jergens AE. Correlating Gastrointestinal Histopathologic Changes to Clinical Disease Activity in Dogs With Idiopathic Inflammatory Bowel Disease. Vet Pathol. 2018 Dec 18:300985818813090. DOI: 10.1177/0300985818813090. PMID:30563436.
(iii) Ophthalmology. This research focuses on ocular surface physiology, tear film dynamics, and topical drug bioavailability in veterinary species. Using fluorophotometry, Schirmer testing, and protein biomarker quantification, these studies characterize the pharmacological and physiological properties of the tear film in both healthy and diseased states. Overall, this portfolio supports the optimization of therapeutic targeting and diagnostics in veterinary and comparative ophthalmology.
Sebbag L, Broadbent VL, Kenne DE, Perrin A, Mochel JP. Albumin in Tears Modulates Bacterial Susceptibility to Topical Antibiotics in Ophthalmology. Front Med (Lausanne). 2021 Nov 30;8:663212. DOI: 10.3389/fmed.2021.663212. PMCID: PMC8669104.
Bertram M, Allbaugh RA, Mochel JP, Peraza J, Page L, Sebbag L. Influence of Schirmer Strip Wetness on Volume Absorbed, Volume Recovered, and Total Protein Content in Canine Tears. Vet Ophthalmol. 2021 Mar 15. DOI: 10.1111/vop.12876. PMID: 33720492.
Terhaar HM, Allbaugh RA, Mochel JP, Sebbag L. Serum Albumin and Total Protein Concentration in the Tear Film of Horses with Healthy or Diseased Eyes. Vet Ophthalmol. 2021;24(1):20-27. DOI: 10.1111/vop.12822. PMID: 32920954.
Page L, Allbaugh R, Mochel JP, Peraza J, Bertram M, Sebbag L. Impact of Diurnal Variation, Sex, Tear CollectionMethod, and Disease State on Tear Protein Levels in Dogs. Vet Ophthalmol. 2020 Nov;23(6):994-1000. DOI:10.1111/vop.12840. PMID: 33118315.
Sebbag L, Uhl LK, Schneider B, Hayes B, Olds J, Mochel JP. Investigation of Schirmer Tear Test-1 for Measurement of Tear Production in Cats in Various Environmental Settings and With Different Test Durations. J Am Vet Med Assoc.2020 Mar 15;256(6):681-686. DOI: 10.2460/javma.256.6.681. PMID: 32125244.
Sebbag L, Soler E, Allbaugh R, Mochel JP. Impact of Acute Conjunctivitis on Ocular Surface Homeostasis in Dogs. VetOphthalmol. 2020 Jul 15. DOI: 10.1111/vop.12804. PMID: 32666689.
Sebbag L, Moody L, Mochel JP. Albumin Levels in Tear Film Modulate The Bioavailability of Medically-Relevant TopicalDrugs. Front Pharmacol. 2020;10:1560. DOI:10.3389 fphar.2019.01560. PMCID: PMC6997149.
Sebbag L, Allbaugh R, Wehrman R, Uhl L, Ben-Shlomo G, Chen T, Mochel JP. Fluorophotometric Assessment of Tear Volume and Turnover Rate in Healthy Dogs and Cats. J Ocul Pharmacol Ther. 2019 Aug 8. DOI:10.1089/jop.2019.0038. PMID: 31381493.
Sebbag L, Allbaugh RA, Weaver A, Seo YJ, Mochel JP. Histamine-Induced Conjunctivitis and Breakdown of Blood-Tear Barrier in Dogs: A Model for Ocular Pharmacology and Therapeutics. Front Pharmacol. 2019 Jul 9;10:752. DOI: 10.3389/fphar.2019.00752. eCollection 2019. PMCID: PMC6629934.
Sebbag L, Showman L, McDowell EM, Perera A, Mochel JP. Impact of Flow Rate, Collection Devices, and ExtractionMethods on Tear Concentrations Following Oral Administration of Doxycycline in Dogs and Cats. J Ocul Pharmacol Ther.2018 Apr 30. DOI: 10.1089/jop.2018.0008. PMID: 29708819.
Sebbag L, McDowell EM, Hepner PM, Mochel JP. Effect of Tear Collection on Lacrimal Total Protein Content in Dogs and Cats: A Comparison Between Schirmer Strips and Ophthalmic Sponges. BMC Vet Res. 2018 Mar 1;14(1):61. DOI:10.1186/s12917-018-1390-7. PMID: 29490661.
Sebbag L, Harrington DM, Mochel JP. Tear Fluid Collection in Dogs and Cats Using Ophthalmic Sponges. VetOphthalmol. 2018 May;21(3):249-254. DOI: 10.1111/vop.12502. PMID:28845579.
IN SILICO MODELING – PHARMACOKINETICS & PHARMACODYNAMICS
This series of studies provides a comparative framework for drug disposition across species, correlating pharmacokinetic variability to formulation, route of administration, disease state, and species-specific physiology. Through the application of nonlinear mixed-effects modeling and in vivo studies, these publications support rational dose selection, optimized therapeutic regimens, and improved animal welfare.
Padhi P, Abdalla A, Schneider B, Backes N, Zenitsky G, Jin H, Anantharam V, Kanthasamy A, Allenspach K, Mochel JP, Phillips GJ, Kanthasamy AG. Sustained Levodopa Delivery by Engineered Live-Biotherapeutic for Parkinson’s Disease. Cell Host Microbe. 2025 Oct 30:S1931-3128(25)00419-6. DOI: 10.1016/j.chom.2025.10.005. PMID: 41172985.
Bailey CS, Beachler TM, Mochel JP, Wulf LW, Yaeger M, Kundu D, Withowski K, Papich MG. Penicillin and Gentamicin Concentrations in the Uterine Fluid of Non-Pregnant Mares Following a Single Intrauterine Infusion. J Vet Pharmacol Ther. 2025 May 14. DOI: 10.1111/jvp.13518. PMID: 40365823.
Bello A, Mochel JP, Jajor P, Bobrek K, Świtała M, Poźniak B. Population Pharmacokinetics and Absolute Oral Bioavailability of Lasalocid after Single Intravenous and Intracrop Administration in Laying Hens. J Agric Food Chem. 2024 Jun 12;72(23):13348-13359. DOI: 10.1021/acs.jafc.4c01164. PMID: 38829852.
McQuinn E, Mochel JP, Borts D, Hanzlicek A, Allenspach K, Palerme JS. Pharmacokinetics of the Antifungal Agent Isavuconazole in Healthy Dogs. PLoS One. 2024 Jul 16;19(7):e0305766. DOI: 10.1371/journal.pone.0305766. PMCID: PMC11251614.
Vasanthi SS, Massey N, Nair SN, Mochel JP, Showman L, Thippeswamy T. Exploring the Benefits of In-Diet Versus Repeated Oral Dosing of Saracatinib (AZD0530) in Chronic Studies: Insights into Pharmacokinetics and Animal Welfare. Front Vet Sci. 2023 Nov 9;10:1297221. DOI: 10.3389/fvets.2023.1297221. PMCID: PMC10666625.
O’Brien M, Mochel JP, Kersh K, Wang C, Troy J. Phenylbutazone Concentrations in Synovial Fluid Following Administration via Intravenous Regional Limb Perfusion in the Forelimbs of Six Adult Horses. Front Vet Sci. 2023 Aug 24;10:1236976. DOI: 10.3389/fvets.2023.1236976. PMCID: PMC10484477.
Smith JS, Gebert JE, Ebner LS, Bennett KO, Collins RJ, Hampton CE, Kleine SA, Mulon PY, Smith CK, Seddighi R, Bussieres G, Mochel JP, Knych HK. Pharmacokinetics of Intramuscular Maropitant in Pigs (Sus scrofa domesticus). J Vet Pharmacol Ther. 2023 Mar 5. DOI: 10.1111/jvp.13120. PMID: 36872454.
Olivarez JD, Mulon PY, Ebner LS, Cremerius H, Cantrell C, Rahn R, Soto-Gonzalez W, Bergman J, Cox S, Mochel JP, Kreuder AJ, Smith JS. Pharmacokinetic and Pharmacodynamic Properties of Pantoprazole in Calves. Front Vet Sci. 2023 Jan 30;9:1101461. DOI: 10.3389/fvets.2022.1101461. PMCID: PMC9923100.
Bello A, Henri J, Veil A, Mochel JP, Pozniak B. Ionophore Coccidiostats – Disposition Kinetics in Laying Hens and Residues Transfer to Eggs. Poult Sci. 2023 Jan;102(1):102280. DOI: 10.1016/j.psj.2022.102280. PMCID: PMC9676626.
Stewart SD, Allen S, Eisenberg B, Sakakeeny K, Hammond TN, Schneider BK, Mochel JP, Zhou T. Comparison of the Pharmacokinetics of Continuous and Intermittent Infusions of Ampicillin-Sulbactam in Dogs with Septic Peritonitis. Am J Vet Res. 2022 Dec 19:1-7. DOI: 10.2460/ajvr.22.08.0139. PMID: 36520648.
Bowden AC, Allbaugh RA, Smith JS, Mochel JP, Sebbag L. Kinetics and Minimal Inhibitory Concentrations of Ceftiofur in Tear Film Following Extended-Release Parenteral Administration (Excede®) in Dogs. Front Vet Sci. 2022 Sep 20;9:975113. DOI: 10.3389/fvets.2022.975113. PMCID: PMC9535610.
Cawley J, Stewart S, Mochel JP, Veluvolu SM, Fenger J. Pharmacokinetic Exposures Associated With Oral Administration of Sorafenib in Dogs with Spontaneous Tumors. Front Vet Sci. 2022 May 19;9:888483. DOI: 10.3389/fvets.2022.888483. PMCID: PMC9162170.
Beyi AF, Mochel JP, Magnin G, Hawbecker T, Slagel C, Dewell G, Dewell R, Sahin O, Coetzee H, Zhang Q, Plummer PJ. Comparisons of Plasma and Fecal Pharmacokinetics of Danofloxacin and Enrofloxacin in Healthy and Mannheimia Haemolytica Infected Calves. Sci Rep. 2022 Mar 24;12(1):5107. DOI: 10.1038/s41598-022-08945-z. PMCID: PMC8948211.
Smith JS, Mochel JP. Pharmacokinetics of Pantoprazole and Pantoprazole Sulfone in Goats after Intravenous Administration: A Preliminary Report. Front Vet Sci. 2021 Sep 22;8:744813. DOI: 10.3389/fvets.2021.744813. PMCID: PMC8492921.
Yaeger M, Mochel JP*, Wu Z, Plummer P, Sahin R, Beyi A, Zhang Q, Griffith R. Pharmacokinetics of Tulathromycin in Pregnant Ewes Challenged with Campylobacter Jejuni. PLoS One. 2021;16(8):e0256862. DOI: 10.1371/journal.pone.0256862. PMID: 34449832.*: corresponding author.
Sebbag L, Kirner NS, Wulf L, Mochel JP. Tear Film Pharmacokinetics and Systemic Absorption of Topical 1% Prednisolone Acetate Ophthalmic Suspension in Dogs. Front Vet Sci. 2020 Oct 27;7:571350. DOI:10.3389/fvets.2020.571350. PMID: 33005646.
Sebbag L, Mochel JP. Pharmacokinetics of Oral Prednisone at Anti-inflammatory to Immunosuppressive in Dogs: ANaïve Pooled-Data Approach. Front Vet Sci. 2020 Oct 19;7:571457. DOI: 10.3389/fvets.2020.571457. eCollection2020. PMID: 33195563.
Olivarez JD, Kreuder AJ, Tatarniuk DM, Wulf LW, Dembek KA, Mochel JP, Smith JS. Pharmacokinetics and Tissue Levels of Pantoprazole in Neonatal Calves After Intravenous Administration. Front Vet Sci. 2020 Nov 27;7:580735. DOI: 10.3389/fvets.2020.580735. PMID: 33330703.
Warner R, Ydstie J, Wulf L, Gehring R, Coetzee J, Mochel JP and Gorden P. Corrigendum: ComparativePharmacokinetics of Meloxicam between Healthy Post-partum versus Mid-lactation Dairy Cattle. Front Vet Sci. 2021 May 26;8:665021. DOI: 10.3389/fvets.2021.665021. eCollection 2021. PMCID: PMC8188475.
Warner R, Ydstie J, Wulf L, Gehring R, Coetzee J, Mochel JP and Gorden P. Comparative Pharmacokinetics of Meloxicam between Healthy Post-Partum versus Mid-lactation Dairy Cattle. Front Vet Sci. 2020 Sep 8;7:548. DOI: 10.3389/fvets.2020.00548. eCollection 2020. PMID: 33102542.
Wang J, Schneider BK, Sun P, Seo YJ, Mochel JP*, Cao X. Nonlinear Mixed-Effects Pharmacokinetic Modeling of theNovel COX-2 Selective Inhibitor Vitacoxib in Cats. Front Vet Sci. 2020 Sep 24;7:554033. DOI: 10.3389/fvets.2020.554033. eCollection 2020. PMID: 33102567. *: corresponding author.
Kittrell HC, Mochel JP, Brown J, Schneider BK, Ratliffe B, Karriker L. Pharmacokinetics and Bioavailability of FlunixinMeglumine in Pre-Wean Piglets Following Oral, Topical, and Intramuscular Routes of Administration. Front Vet Sci.2020 Aug 28;7:586. DOI: 10.3389/fvets.2020.00586. PMID: 33005646.
Sebbag L, Kirner N, Allbaugh R, Mochel JP. Pharmacokinetics of Topical Drug Delivery: Does Size Really Matter? Front Vet Sci. 2019 Dec 19;6:457. DOI: 10.3389/fvets.2019.00457. PMID: 31921915.
Musser M, Mahaffey AL, Fath M, Buettner G, Brett W, Schneider B, Seo YJ, Mochel JP, Johannes CM. In vitroCytotoxicity and Pharmacokinetic Evaluation of Pharmacological Ascorbate in Dogs. Front Vet Sci. 2019 Nov 7;6:385. DOI: 10.3389/fvets.2019.00385. PMID: 31788483.
Smith JS, Borts DJ, Slagel CC, Rajewski SM, Bousquet-Melou A, Ferran AA, Plummer PJ, Mochel JP. Pharmacokinetics of Ertapenem in Sheep (Ovis aries) with Experimentally Induced Urinary Tract Infection. Comp Med. 2019 Oct 1;69(5):413-418. DOI: 10.30802/AALAS-CM-18- 000144. PMID: 31581974.
Wang J, Schneider BK, Xue J, Sun P, Qiu J, Mochel JP*, Cao X. Pharmacokinetic Modeling of Ceftiofur Sodium Using Non-linear Mixed-Effects in Healthy Beagle Dogs. Front Vet Sci. 2019 Oct 17;6:363. DOI: 10.3389/fvets.2019.00363.PMID: 31681816. *: corresponding author.
Sebbag L, Yan Y, Smith JS, Allbaugh RA, Wulf LW, Mochel JP. Tear Fluid Pharmacokinetics Following Oral PrednisoneAdministration in Dogs With and Without Conjunctivitis. J Ocul Pharmacol Ther. 2019 May 9. DOI:10.1089/jop.2019.0020. PMID: 31070497.
Wang J, Sun P, Li J, Pei Y, Schneider BKS, Seo YJ, Mochel JP* and Cao X*. Nonlinear Mixed-Effects Pharmacokinetic Modeling of the Novel COX-2 Selective Inhibitor Vitacoxib in Dogs. J Vet Pharmacol Ther. 2019. DOI:10.1111/jvp.12802. PMID: 31369157. *: co- corresponding author.
Smith JS, Mochel JP, Borts D, Griffith R. Effects of Experimentally-Induced Respiratory Disease on the Pharmacokinetics and Tissue Disposition of Tulathromycin in Meat Goats. J Vet Pharmacol Ther. 2019 Jun 10. DOI:10.1111/jvp.12764. PMID: 31183876.
Moczarnik J, Berger DJ, Noxon JO, LeVine DN, Lin Z, Coetzee JF, Mochel JP. Relative Oral Bioavailability of Two Amoxicillin-Clavulanic Acid Formulations in Healthy Dogs: A Pilot Study. J Am Anim Hosp Assoc. 2019 Jan/Feb;55(1):14-22. DOI: 10.5326/JAAHA-MS-6872. Nov 14. PMID: 30427713.
Smith JS, Mochel JP, Borts DJ, Lewis KA, Coetzee JF. Adverse Reactions to Fentanyl Transdermal Patches in Calves: A Preliminary Clinical and Pharmacokinetic Study. Vet Anaesth Analg. 2018 Jul;45(4):575-580. DOI:10.1016/j.vaa.2018.02.009. PMID: 29880278.
Smith JS, Coetzee JF, Fisher IWG, Borts DJ, Mochel JP. Pharmacokinetics of Fentanyl Citrate and Norfentanyl in Holstein Calves and Effect of Analytical Performances on Fentanyl Parameter Estimation. J Vet Pharmacol Ther. 2018 Aug;41(4):555-561. DOI: 10.1111/jvp.12501. PMID: 29603262.
Gorden PJ, Ydstie JA, Kleinhenz MD, Brick TA, Smith JS, Griffith RW, Wulf LW, Rajewski SM, Zhang M, Sidhu PK, Mochel JP, Coetzee JF. Comparative Plasma and Interstitial Fluid Pharmacokinetics and Tissue Residues of Ceftiofur Crystalline-Free Acid in Cattle with Induced Coliform Mastitis. J Vet Pharmacol Ther. 2018 Jul 4. DOI:10.1111/jvp.12688. PMID: 29971798.
Gorden PJ, Burchard M, Ydstie JA, Kleinhenz MD, Wulf LW, Rajewski SJ, Wang C, Gehring R, Mochel JP, Coetzee JF. Comparison of Milk and Plasma Pharmacokinetics of Meloxicam in Postpartum versus Mid-Lactation Holstein cows. JVet Pharmacol Ther. 2018 Jun;41(3):463-468. DOI: 10.1111/jvp.12488. PMID: 29430684.
Pelligand L, Soubret A, King JN, Elliott J, Mochel JP. Modeling of Large Pharmacokinetic Data Using Nonlinear Mixed-Effects: A Paradigm Shift in Veterinary Pharmacology. A Case Study With Robenacoxib in Cats. CPT Pharmacometrics Syst Pharmacol. 2016 Nov;5(11):625-635. DOI: 10.1002/psp4.12141. PMID: 27770596.
Fink M, Letellier I, Peyrou M, Mochel JP, Jung M, King JN, Gruet P, Giraudel JM. Population Pharmacokinetic Analysis of Blood Concentrations of Robenacoxib in Dogs with Osteoarthritis. Res Vet Sci. 2013 Oct;95(2):580-7. DOI: 10.1016/j.rvsc.2013.04.021. PMID: 23726662.
IN VITRO MODELING – STEM CELLS
This research program pioneers adult stem cell–derived 3D organoid systems, primarily from canine and other veterinary tissues, as physiologically relevant models for translational research. These organoids recapitulate key structural and functional features of their organs of origin, enabling studies of epithelial barrier integrity, inflammatory signaling, metabolic adaptation, and drug permeability. Collectively, these studies position organoid platforms as robust, ethically aligned alternatives to animal testing and as next-generation tools for precision therapeutics in both human and veterinary medicine.
Zdyrski C, Gabriel V, Ospina O, Wickham H, Sahoo DK, Dao K, Honold S, Piñeyro P, Allenspach K, Mochel JP. Establishment and Transcriptomic Characterization of Canine Organoids from Multiple Tissues. Front Cell Dev Biol. 2025 Nov 24;13:1680376. doi: 10.3389/fcell.2025.1680376. PMCID: PMC12686805.
Nicholson H, Zdyrski C, Corbett MP, Lowen AC, Catucci M, Melvin BJ, Stabler LJ, Douglass E, Mochel JP, Allenspach K, Carnaccini S. Development and Characterization of Chicken Lung Organoids for Future In Vitro Modeling of Avian Influenza Virus-Host Cell Interaction. Sci Rep. (In Press).
Peterson H, Zdyrski C, Allenspach K, Mochel JP, Trepanier LA. Urothelial Genotoxicity of Household Chemicals in Healthy Canine Urinary Bladder Organoids Relative to Observed Urinary Exposures in Pet Dogs. Front Vet Sci. (In Press).
Moshksayan K, Khanna R, Camli B, Nevra Yakay Z, Harihara A, Zdyrski C, Mondal S, Hegarty E, Mochel JP, Allenspach K, Ben-Yakar A. A Microfluidic Platform for Culturing, Staining, Immobilization, and High-Content Imaging of Adult Stem Cell-Derived Organoids. Sci Rep. 2025 Nov 17;15(1):40162. DOI: 10.1038/s41598-025-23883-2. PMCID: PMC12623891.
Corbett MP, Gabriel V, Livania V, Díaz-Regañón D, Ralston A, Zdyrski C, Liu D, Minkler S, Wickham H, Lincoln A, Paukner K, Atherly T, Merodio MM, Sahoo DK, Meyerholz DK, Allenspach K, Mochel JP. A Preclinical Model to Assess Intestinal Barrier Integrity Using Canine Enteroids and Colonoids. Biology (Basel). 2025 Mar 6;14(3):270. DOI: 10.3390/biology14030270. PMCID: PMC11939752.
Kothadiya S, Cutshaw G, Uthaman S, Hassan N, Sahoo DK, Wickham H, Allenspach K, Mochel JP, Bardhan R. Cisplatin-Induced Metabolic Responses Measured with Raman Spectroscopy in Cancer Cells, Spheroids, and Canine-derived Organoids. ACS Appl Mater Interfaces. 2024 Sep 25;16(38):50267-50281. DOI: 10.1021/acsami.4c08629. Epub 2024 Sep 16. PMID: 39284013.
Gabriel V, Zdyrski C, Ralston A, Wickham H, Honold S, Lincoln A, Ahmed BH, Paukner K, Piñeyro P, Allenspach K, Mochel JP. Evaluation of Different Media Compositions Promoting Hepatocyte Differentiation in the Canine Liver Organoid Model. Heliyon. 2024 Mar 25;10(7):e28420. DOI: 10.1016/j.heliyon.2024.e28420. PMCID: PMC10999936.
Zdyrski C, Gabriel V, Gessler T, Wickham H, Bista B, Honold S, Topping N, Sahoo DK, Piñeyro P, Allenspach K, Mochel JP, Valenzuela N. Supercooling Potential of the First Turtle Organoid Biobank. Commun Biol. 2024 Feb 22;7(1):218. doi: 10.1038/s42003-024-05818-1. PMCID: PMC10883927.
Moshksayan K, Harihara A, Mondal S, Hegarty E, Sahoo DK, Jergens AE, Mochel JP, Allenspach K, Zoldan J and Ben-Yakar A. OrganoidChip Facilitates Immobilization and Fast Imaging of Organoids. Sci Rep. 2023 Jul 12;13(1):11268. DOI: 10.1038/s41598-023-38212-8. PMCID: PMC10338466.
Sahoo DK, Martinez MN, Dao K, Gabriel V, Zdyrski C, Jergens AE, Atherly T, Iennarella-Servantez CA, Burns LE, Schrunk D, Volpe DA, Allenspach K, Mochel JP. Canine Intestinal Organoids as a Novel In Vitro Model of Intestinal Drug Permeability: A Proof-of-Concept Study. Cells. 2023 Apr 27;12(9):1269. DOI: 10.3390/cells12091269. PMCID: PMC10177590.
Díaz-Regañón D, Gabriel V, Livania V, Liu D, Ahmed BH, Lincoln A, Wickham H, Ralston A, Merodio MM, Sahoo DK, Meyerholz D, Mochel JP and Allenspach K. Changes of Enterocyte Morphology and Enterocyte:Goblet Cell Ratios in Dogs with Protein-Losing and Non-Protein-Losing Chronic Enteropathies. Vet Sci. 2023 Jun 27;10(7):417. DOI: 10.3390/vetsci10070417. PMCID: PMC10383676.
Bedos L, Gabriel V, Zdyrski C, Allbaugh R, Sebbag L, Mochel JP, Allenspach K. Culture and Characterization of Canine and Feline Corneal Epithelial Organoids: A New Tool for the Study and Treatment of Corneal Diseases. Front Vet Sci. 2022 Nov 4;9:1050467. DOI: 10.3389/fvets.2022.1050467. PMCID: PMC9672346.
Sahoo DK, Borcherding DC, Chandra L, Jergens AE, Atherly T, Bourgois-Mochel A, Ellinwood NM, Snella E, Severin AJ, Martin M, Allenspach K, Mochel JP. Differential Transcriptomic Profiles Following Stimulation with Lipopolysaccharide in Intestinal Organoids from Dogs with Inflammatory Bowel Disease and Intestinal Mast Cell Tumor. Cancers. 2022; 14(14):3525. DOI: 14143525. PMCID: PMC9322748.
Gabriel V, Zdyrski C, Sahoo D, Dao K, Bourgois-Mochel A, Kopper J, Mochel JP*, Allenspach K*. Standardization and Maintenance of 3D Canine Hepatic and Intestinal Organoids for Use in Biomedical Research. *: co-corresponding authors. J Vis Exp. 2022 Jan 31;(179). DOI: 10.3791/63515. PMID: 35156656.
Gabriel V, Zdyrski C, Sahoo DK, Dao K, Bourgois-Mochel A, Atherly T, Martinez MN, Volpe DA, Kopper J, Allenspach K, Mochel JP. Canine Intestinal Organoids in a Dual-Chamber Permeable Support System. J Vis Exp. 2022 Mar 2;(181). DOI: 10.3791/63612. PMID: 35311824.
Shanahan MT, Kanke M, Oyesola OO, Hung YH, Koch-Laskowski K, Singh AP, Peck BCE, Biraud M, Sheahan B, Cortes JE, Gong H, Sahoo DK, Cubitt R, Kurpios NA, Mochel JP, Allenspach K, McElroy SJ, Ding S, von Moltke J, Dekaney CM, Tait-Wojno ED, Sethupathy P. Multiomic Analysis Defines the First MicroRNA Atlas Across all Small Intestinal Epithelial Lineages and Reveals Novel Markers of Almost All Major Cell Types. Am J Physiol Gastrointest Liver Physiol. 2021 Dec 1;321(6):G668-G681. DOI: 10.1152/ajpgi.00222.2021. PMCID: PMC8887887.
Ambrosini YM, Park Y, Jergens AE, Shin W, Mon S, Atherly T, Borcherding DC, Jang J, Allenspach K, Mochel JP* and Kim HY*. Recapitulation of an Accessible Interface of the Biopsy-Derived Canine Intestinal Organoids to Study Epithelial-Luminal Interactions. PLoS One. 2020 Apr 17;15(4):e0231423. DOI: 10.1371/journal.pone.0231423. PMID: 32302323. *: co-corresponding authors.
Chandra L, Borcherding DC, Kingsbury D, Atherly T, Ambrosini YM, Bourgois-Mochel A, Yuan W, Kimber M, Qi Y, Wang Q, Wannemuehler M, Ellinwood NM, Snella E, Martin M, Skala M, Meyerholz D, Estes M, Fernandez-Zapico ME, Jergens AE, Mochel JP*, Allenspach K*. Derivation of Adult Canine Intestinal Organoids for Translational Research in Gastroenterology. BMC Biol. 2019 Apr 11;17(1):33. DOI: 10.1186/s12915-019-0652-6. PMID: 30975131.* co-corresponding authors.
VETERINARY CLINICAL SCIENCES
This series of clinical studies centers on emergency/critical care, cardiology, and internal medicine. Many of these publications integrate pharmacologic analysis with clinical outcome data, such as dose–response evaluations. Several are multi-institutional studies addressing risk factors, treatment efficacy, and adverse event profiling in real-world clinical populations.
Odunayo A, Kundu D, Walton R, Bilof J, Scharf V, Mochel JP, Solari F, McPhetridge J, Mickelson M. Evaluation of Risk Factors Predicting Complications Associated with Perineal Urethrostomy in Cats with Urethral Obstruction (2009-2019): A Retrospective, Multi-Institutional Study: 140 Cases. J Vet Emerg Crit Care. (In Press).
Neufeld MR, Hanson KR, Mochel JP, Cai J, Raffe MR, Handel A, Julius T. Transmucosal Detomidine Gel Induces Emesis in Approximately Half of Cats Presenting for Dietary Indiscretion. JAVMA. (In Press).
Boules M, Zorn CM, Kundu D, Mochel JP, Walton RAL. Retrospective Comparison of Outcomes From Septic Peritonitis of Gastrointestinal Versus Non-Gastrointestinal Etiology in Dogs (2009-2022): 161 Cases. J Vet Emerg Crit Care (San Antonio). 2025 Nov 20. DOI: 10.1111/vec.70056. PMID: 41267510.
To A, Hall J, Mallard M, Kundu D, Mochel JP, Walton RAL. Retrospective Evaluation of Treatment and Survival of Blunt Trauma-Associated Pneumothorax in Dogs: 89 Cases (2018-2022). J Vet Emerg Crit Care (San Antonio). 2025 Oct 15. DOI: 10.1111/vec.70035. PMID: 41088872.
Lovell T, Goyen K, Kundu D, Mochel JP, Walton RA. Retrospective Evaluation of the Incidence and Risk Factors Associated with the Development of a Hepatopathy in Xylitol Ingestion: 95 Dogs (2018-2022). J Vet Emerg Crit Care (San Antonio). 2025 Oct 7. DOI: 10.1111/vec.70041. PMID: 41056358.
Gabriel L, Walton R, Young T, Cai J, Mochel JP, Peterson K. Incidence of Hypernatremia in Dogs Treated with Multi-Dose Activated Charcoal for Acute Toxicant Ingestion: Multi-Center Retrospective Study (2018-2023). Front Vet Sci. 2025 May 12;12:1584162. DOI: 10.3389/fvets.2025.1584162. PMCID: PMC12104289.
Young T, Walton R, Cheng P, Cai J, Mochel JP, Peterson K. Incidence of Hypernatremia in Dogs Treated with Single Dose Activated Charcoal for Acute Toxin Ingestion: Multi-Center Retrospective Study (2018-2023). Front Vet Sci. 2025 Feb 26;12:1547076. DOI: 10.3389/fvets.2025.1547076. PMC11897026.
Ngo L, Walton R, Wolf J, Levy N, Ludwik T, Thevelein B, Blong A, Cai J, Mochel J. The Association Between Non-Depolarizing Neuromuscular Blockade Agents and Survival to Discharge in Dogs Undergoing Mechanical Ventilation: A Multi-Center Retrospective Study of 227 Dogs (2010-2020). Front Vet Sci. 2025 Mar 5;12:1539138. DOI: 10.3389/fvets.2025.1539138. PMCID: PMC11921043.
Schiavone S, Blong AE, Buseman M, Reyes B, Scharf V, Yuan L, Mochel JP, Walton RAL. Retrospective Evaluation of Complications Associated With Surgically Placed Gastrostomy Tubes in Dogs (2010-2020): 133 Cases. J Vet Emerg Crit Care (San Antonio). 2025 Mar 24:e13452. DOI: 10.1111/vec.13452. PMID: 40127429.
Yee M, Guillaumin J, Hoen M, Cai J, Mochel JP, Walton R. Utilization of Peripheral Glucose and Lactate Differences in the Diagnosis of Feline Arterial Thromboembolism: A Multi-center Study. Front Vet Sci. 2024 Dec 4;11:1505479. DOI: 10.3389/fvets.2024.1505479. PMCID: PMC11652598.
Rogg S, Mochel J, Kundu D, Tropf M, Masters A, Adin D, Ward J. Frequency and Progression of Azotemia During Acute and Chronic Treatment of Congestive Heart Failure in Cats. J Vet Intern Med. 2025 Jan-Feb;39(1):e17254. DOI: 10.1111/jvim.17254. Epub 2024 Nov 26. PMCID: PMC11638122.
Flynn R, Cremerius H, Ebner L, Mulon PY, Jessica Garcia, Kailee Bennett, Jessica Gebert, Harvill L, Escher O, Cantrell C, Soto-Gonzalez W, Rahn RR, Olivarez JD, Yuan L, Mochel JP, Kreuder AJ, Smith J. Evaluating the Bias of Two Point-of-Care Glucometers for Calves and Ewes: Awareness for Ruminant Practitioners. Ruminants 2024(4):304-315. DOI: 10.3390/ruminants4030022.
Van Vertloo LR, Sebbag L, Allbaugh RA, Allenspach K, Borts DJ, Mochel JP. Systemic Absorption and Gastrointestinal Adverse Effects from Topical Ketorolac and Diclofenac Ophthalmic Solutions in Healthy Dogs. J Am Vet Med Assoc. 2024 Apr 5:1-10. DOI: 10.2460/javma.23.12.0707. PMID: 38579753.
Copeland AT, Kreuder AJ, Dewell G, Dewell R, Wiley C, Yuan L, Mochel JP and Smith JS. Randomized Comparison Between a Forced Air Delivery System and Warm Water Bath for Neonatal Calf Hypothermic Resuscitation with or without Adjunct Oral Caffeine Administration. J Vet Intern Med. 2024 May-Jun;38(3):1941-1950. DOI: 10.1111/jvim.17066. PMCID: PMC11099694.
Rosario CO, Musser ML, Yuan L, Mochel JP, Talbott J, Johannes CM, Berger EP. Retrospective Evaluation of Toceranib Phosphate (Palladia) Use in the Treatment of Feline Pancreatic Carcinoma. Can Vet J. 2023 Dec;64(12):1143-1148. PMCID: PMC10637710.
Solari FP, Mickelson MA, Bilof J, Odunayo A, McPhetridge JB, Scharf VF, Yuan L, Mochel JP, Walton RA. Retrospective Evaluation of the Prevalence and Risk Factors Associated with Red Blood Cell Transfusions in Cats with Urethral Obstruction (2009-2019): 575 cases. J Vet Emerg Crit Care (San Antonio). 2024 May-Jun;34(3):262-267. DOI: 10.1111/vec.13378. PMID: 38728082.
Kilburn LR, Allenspach K, Jergens AE, Bourgois-Mochel A, Mochel JP, Serao MCR. Apparent Total Tract Digestibility,Fecal Characteristics, and Blood Parameters of Healthy Adult Dogs Fed High-Fat Diets. J Anim Sci. 2020 Mar 1;98(3):skaa043. DOI: 10.1093/jas/skaa043. PMID: 32047902.
Barron LZ, DeFrancesco TC, Chou YY, Bonagura JD, Tropf MA, Murphy SD, McManamey AK, Yuan L, Mochel JP, Ward JL. Echocardiographic Caudal Vena Cava Measurements in Healthy Cats And in Cats with Congestive Heart Failure and Non-Cardiac Causes of Cavitary Effusions. J Vet Cardiol. 2023 May 10;48:7-18. DOI: 10.1016/j.jvc.2023.05.004. PMID: 37276765.
Bunnell N, Walton RA, Yuan L, Mochel JP, Blong A. Blood Product Usage and Factors Associated with Transfusions in Cats with Hemoperitoneum: 33 cases (2018-2022). Front Vet Sci. 2023 Jul 13;10:1204864. DOI: 10.3389/fvets.2023.1204864. PMCID: PMC10372415.
Zorn CM, Walton RAL, McKeen L, Mochel JP, Ward M, Blong AE. Retrospective Comparison of Outcomes in Septic Peritonitis With or Without Closed-Suction Abdominal Drainage in 115 Dogs (2009-2019). Vet Anim Sci. 2023 Jul 14;21:100304. DOI: 10.1016/j.vas.2023.100304. PMCID: PMC10474222.
Page LE, Kubai MA, Allbaugh RA, Roy MM, Mochel JP, Sebbag L. Increased Drug Concentration and Repeated Eyedrop Administration as Strategies to Optimize Topical Drug Delivery in Dogs. Vet Ophthalmol. 2023 Jul;26(4):331-338. DOI: 10.1111/vop.13125. PMID: 37353948.
Walton R, Riha J, Swor T, Kopper J, Yuan L, Mochel J, T Hoen M, Blong A. Comparison of Traditional Didactic vs. Additional Hands-on Simulation Training in the Performance of Basic Life Support in Veterinary Students – A Prospective, Blinded, Randomized Study. J Vet Med Educ. 2023 Apr 27:e20220121. DOI: 10.3138/jvme-2022-0121. PMID: 37104287.
Buseman M, Blong AE, Yuan L, Mochel JP, Walton RAL. Retrospective Evaluation of Admission Total Plasma Protein as a Predictor of Red Blood Cell Transfusion Requirement in Dogs Diagnosed with Traumatic and Nontraumatic Hemoabdomen: 90 dogs (2009-2019). J Vet Emerg Crit Care (San Antonio). 2023 Nov 13. DOI: 10.1111/vec.13343. PMID: 37961036.
Perrucci J, Yuan L, Mochel JP, Walton R. Retrospective Evaluation of the Effect of General Anesthesia on Complications and Recurrence Rates in Feline Urethral Obstruction. J Feline Med Surg. 2023 Feb;25(2):1098612X221149348. DOI: 10.1177/1098612X221149348. PMID: 36745058.
Musser ML, Coto GM, Yuan L, Mochel JP, Johannes CM. Pilot Safety Evaluation of Doxorubicin Chemotherapy Combined with Non-Specific Immunotherapy (Immunocidin®) for Canine Splenic Hemangiosarcoma. PLoS One. 2022 Dec 22;17(12):e0279594. DOI: 10.1371/journal.pone.0279594. PMCID: PMC9778498.
Sherman A, Hawbecker T, Yuan L, Mochel JP, Mickelson MA. Short-term Complications Associated with ProphylacticGastropexy Performed During Abdominal Exploratory for Emergency Gastrointestinal Surgery. Vet Surg. 2022 Nov 16. DOI: 10.1111/vsu.13911. PMID: 36382668.
Giorgi ME, Mochel JP, Yuan L, Adin DB, Ward JL. Risk Factors for Development of Kidney Injury after Parenteral Furosemide Treatment of Left-Sided Congestive Heart Failure in Dogs. J Vet Intern Med. 2022 Oct 18. DOI: 10.1111/jvim.16571. PMID: 36254646.
Walton R, Stroope S, Mochel JP, Yuan L, Enders B. Retrospective Evaluation of Clinical Bleeding in Dogs with Anticoagulant Rodenticide Toxicity. A Multicenter Evaluation (2010-2020). Front Vet Sci. 2022 May 23;9:879179. DOI: 10.3389/fvets.2022.879179. PMCID: PMC9168750.
Ward JL, Guillot E, Ware WA, Yuan L, Mochel JP. Renin-Angiotensin-Aldosterone System Activity in Cats with Systemic Hypertension or Cardiomyopathy. 2022. J Vet Intern Med. 2022 May;36(3):897-909. DOI: 10.1111/jvim.16401. PMCID: PMC9151484.
Eby A, Early P, Roe S, Kraus K, Yuan L, Mochel JP. Computed Tomographic Evaluation of Mid-Thoracic Vertebral Corridors in Normal French Bulldogs. EJ-VETMED. 2022 Feb. DOI: 10.24018/ejvetmed.2022.2.1.21.
Chou YY, Ward JL, Barron LZ, Murphy SD, Tropf MA, Lisciandro GR, Yuan L, Mochel JP, DeFrancesco TC. Focused Ultrasound of the Caudal Vena Cava in Dogs with Cavitary Effusions or Congestive Heart Failure: A Prospective, Observational Study. PLoS One. 2021 May 28;16(5):e0252544. DOI: 10.1371/journal.pone.0252544. PMID: 34048483.
Evans J, Ward J, Domenig O, Mochel JP, Creevy KE. The Use of a RAAS Profile to Diagnose Hyper-Reninism in a Cat with a Malignant Renal Neoplasm. J Vet Intern Med. 2021 DOI: 10.1111/jvim.16329. PMID: 34859924.
Schmitt EM, Early P, Bergman R, Riedesl EA, Yuan L, Mochel JP, Kraus KH. Computed Tomography Evaluation ofProposed Implant Corridors in Canine Thoracic Vertebrae, T1-T9. Vet Surg. 2021 Jul 12. DOI: 10.1111/vsu.13680. PMID: 34251686.
Naiman JH, Zellner EM, Petrovsky BL, Riegel TO, Schmitt EM, Yuan L, Mochel JP, Kraus KH. Radiation Exposure Associated with Percutaneous Fluoroscopically Guided Lag Screw Fixation for Sacroiliac Luxation in Dogs. Vet Surg. 2021 May 6. DOI: 10.1111/vsu.13613. PMID: 33955568.
Petrovsky B, Knuth T, Aponte-Colón C, Hoefle W, Kraus K, Naiman J, Yuan L, Mochel JP, Zellner E. Short-Term Outcomes of 59 Dogs Treated for Ilial Body Fractures with Locking or Non-Locking Plates. Vet Surg. 2021 May 6. DOI: 10.1111/vsu.13656. PMID: 33955036.
Locklear TR, Videla R, Breuer RM, Mulon PY, Passmore M, Mochel JP, Gerhold R, Schaefer JJ, Smith JS. Presentation, Clinical Pathology Abnormalities, and Identification of Gastrointestinal Parasites in Camels Presenting to Two North American Veterinary Teaching Hospitals. A Retrospective Study: 1980-2020. Front Vet Sci. 2021 Mar 22;8:651672. DOI: 10.3389/fvets.2021.651672. PMID: 33829053.
Hanson KR, Rudloff E, Yuan L, Mochel JP, Linklater AK. Effect of Prazosin on Feline Recurrent Urethral Obstruction. J Feline Med Surg. 2021 Mar 22:1098612X211001283. DOI: 10.1177/1098612X211001283. PMID: 33749375.
Coto GM, Musser ML, Tropf MA, Ward JL, Seo YJ, Mochel JP, Johannes CM. A Multi-Institutional Retrospective Analysis of Toceranib Phosphate for Presumed or Confirmed Canine Aortic Body Chemodectomas. Front Vet Sci. 2021 Feb 5;8:635057. DOI: 10.3389/fvets.2021.635057. PMID: 33614771.
Smith JS, Mochel JP, Seo YJ, Ahrens AP, Griffith RW. Preliminary Evaluation of a Pasteurella Multocida Respiratory Disease Induction Model for Goats. Comp Med. 2020 Sep 9. DOI: 10.30802/AALAS-CM-20-000002. PMID: 32907695.
Ward J, Mochel JP, Seo YJ, Sathe S. Effects of the Estrous Cycle and Pregnancy Status on Cardiovascular Variables inHealthy Bitches. J Vet Cardiol. 2020 Aug;30:57-68. DOI: 10.1016/j.jvc.2020.05.004. PMID: 32688281.
Smith JS, Kosusnik AR, Mochel JP. A Retrospective Clinical Investigation of the Safety and Adverse Effects of Pantoprazole in Hospitalized Ruminants. Front Vet Sci. 2020 Mar 17;7:97. DOI: 10.3389/fvets.2020.00097. PMID:32258063.
Sebbag L, Moody LM, Allbaugh RA, Mochel JP. Nerve Growth Factor in Dogs: Assessment of Two Immunoassays and Selected Ocular Parameters Following a Nicergoline Challenge Per Os. Vet Ophthalmol. 2020 Jan;23(1):199-204. DOI: 10.1111/vop.12723. PMID: 31774231.
Smith JS, Kreuder A, Dowling P, Dohlman T, Plummer P, Toutain PL, Mochel JP. Risks of Antimicrobial Resistance with the Treatment of Bovine Semen with Enrofloxacin. Biopreserv Biobank. 2020 Feb;18(1):41-42. DOI:10.1089/bio.2019.0068. PMID: 31339769.
Lerch M, Allbaugh R, Sebbag L, Mochel JP, Weller P, Borts DJ. Paper Spray High-Resolution Accurate Mass Spectrometry for Quantitation of Voriconazole in Equine Tears. Anal Bioanal Chem. 2019 May 23. DOI:10.1007/s00216-019-01898-9. PMID: 31123782.
Uhl LK, Saito A, Iwashita H, Maggs DJ, Mochel JP, Sebbag L. Clinical Features of Cats with Aqueous Tear Deficiency: A Retrospective Case Series of 10 Patients (17 Eyes). J Feline Med Surg. 2018 Nov 12:1098612X18810867. DOI:10.1177/1098612X18810867. PMID: 30417738.
Berger EP, Johannes CM, Jergens AE, Allenspach K, Powers BE, Du Y, Mochel JP, Fox LE, Musser ML. RetrospectiveEvaluation of Toceranib Phosphate (Palladia) Use in the Treatment of Gastrointestinal Stromal Tumors of Dogs. J Vet Intern Med. 2018 Nov;32(6):2045-2053. DOI: 10.1111/jvim. PMID: 30307656.
LARGE-SCALE HUMAN COHORT STUDIES
This portfolio combines population-based analytics with quantitative modeling to uncover predictors of disease resilience and therapeutic response across scales. Using large human cohorts such as the UK Biobank and ADNI, these studies apply advanced machine learning to integrate neuroimaging, vascular, metabolic, inflammatory, genetic, and lifestyle factors, identifying determinants of cognitive aging, super-aging, and neurodegeneration. In parallel, translational and mechanistic oncology modeling applies nonlinear and population pharmacometrics to characterize tumor growth, optimize dosing schedules, and improve efficacy predictions in non–small cell lung cancer using large clinical datasets. Together, this body of work spans large human cohort analyses to in silico modeling of treatment response, bridging population data with predictive pharmacology.
Schneider B, Benzekry S, Mochel JP. Joint Modeling of First-Line Therapeutics in Non-Small Cell Lung Cancer Using Large Database Reveals Potential Benefits of Scheduling Optimization. CPT Pharmacometrics Syst Pharmacol. 2025 Jul 29. DOI: 10.1002/psp4.70079. PMID: 40729673.
Mohammadiarvejeh P, Fili M, Dawson A, Klinedinst BS, Wang Q, Moody S, Barnett N, Pollpeter A, Larsen B, Li T, Willette SA, Mochel JP, Allenspach K, Hu G, Willette AA. A Multi-Stage Feature Selection Method to Improve Classification of Potential Super-agers and Cognitive Decliners Using Structural Brain MRI Data-A UK Biobank Study. Geroscience. 2024 Dec 10. DOI: 10.1007/s11357-024-01458-9. PMID: 39656405.
Mohammadiarvejeh P, Fili M, Klinedinst BS, Wang Q, Moody S, Barnett N; Pollpeter A, Larsen B, Li T, Willette SA, Mochel JP, Allenspach K, Hu G, Willette AA. A Machine Learning Approach for Potential Super-Agers Identification Using Neural Connectivity Networks. Alzheimers Dement (Amst). Alzheimers Dement (Amst). 2024 Jul 31;16(3):e12619. DOI: 10.1002/dad2.12619. PMCID: PMC11163506.
Klinedinst BS, Kharate MK, Mohammadiarvejeh P, Fili M, Pollpeter A, Larsen BA, Moody S, Wang Q, Allenspach K, Mochel JP, Willette AA. Exploring the Secrets of Super-Aging: a UK Biobank Study on Brain Health and Cognitive Function. Geroscience. 2023 Mar 22. DOI: 10.1007/s11357-023-00765-x. PMID: 36947307.
Mohammadiarvejeh P, Klinedinst BS, Wang Q, Li T, Larsen B, Pollpeter A, Moody SN, Willette SA, Mochel JP, Allenspach K, Hu G, Willette AA. Bioenergetic and Vascular Predictors of Potential Super-Ager and Cognitive Decline Trajectories – a UK Biobank Random Forest Classification Study. Geroscience. 2022. DOI: 10.1007/s11357-022-00657-6. PMID: 36104610.
Klinedinst BS, Le ST, Larsen B, Pappas C, Hoth NJ, Pollpeter A, Wang Q, Wang Y, Yu S, Wang L, Allenspach K, Mochel JP, Willette AA. Using Machine Learning to Predict COVID-19 Infection and Severity Risk Among 4,510 Aged Adults: a UK Biobank cohort study. Sci Rep. 2022 May 11;12(1):7736. DOI: 10.1038/s41598-022-07307-z. PMCID: PMC9092926.
Willette AA, Pappas C, Hoth N, Wang Q, Klinedinst B, Willette SA, Larsen B, Pollpeter A, Li T, Le S, Collazo-Martinez AD, Mochel JP, Allenspach K, Dantzer R; Alzheimer’s Disease Neuroimaging Initiative. Inflammation, Negative Affect, and Amyloid Burden in Alzheimer’s Disease: Insights from the Kynurenine Pathway. Brain Behav Immun. 2021 Mar 25:S0889-1591(21)00121-5. DOI: 10.1016/j.bbi.2021.03.019. PMID: 33775832.
Vaghi C, Rodallec A, Fanciullino R, Ciccolini J, Mochel JP, Mastri M, Ebos JML, Poignard C, Benzekry S. Population Modeling of Tumor Growth Curves Identifies a Reduced Gompertz Model and Improves Prediction of Tumor InitiationTime. PLoS Comput Biol. 2020;16(2):e1007178. DOI:10.1371/journal.pcbi.1007178. PMID: 32097421.
Pappas C, Klinedinst BS, Le S, Wang Q, Larsen B, McLimans K, (…), Allenspach K, Mochel JP, Willette A. CSF Glucose Tracks Regional Tau Progression Based on Alzheimer’s Disease Risk Factors. Alzheimers Dement (NY). 2020Aug 24;6(1):e12080. DOI: 10.1002/trc2.12080. PMID: 32864418.
Klinedinst BS, Meier NF, Mochel JP, Allenspach K, Bennett D, Willette AA. Walking In the Light: How History of Physical Activity, Sunlight, and Vitamin D Levels Account For DEXA-Quantified Body Fat Volumes – a UK BiobankStudy. Obesity (Silver Spring). 2020 Aug;28(8):1428-1437. DOI: 10.1002/oby.22852. PMID: 32573118.
Klinedinst BS, Le ST, Larsen B, Pappas C, Hoth NJ, Pollpeter A, Wang Q, Wang Y, Yu S, Wang L, Allenspach K, Mochel JP, Bennett DA, Willette AA. Genetic Factors of Alzheimer’s Disease Modulate How Diet is Associated with Long-Term Cognitive Trajectories: A UK Biobank Study. J Alzheimers Dis. 2020;78(3):1245-1257. DOI: 10.3233/JAD-201058. PMID: 33252089.
McLimans KE, Collazo Martinez AD, Mochel JP, Allenspach K, Willette AA; Alzheimer’s Disease Neuroimaging Initiative; Australian Imaging Biomarkers and Lifestyle Flagship Study of Ageing. Serum Vitamin B12, and RelatedMTRR and Cubilin Genotypes, Predict Neural Outcomes across the AD Spectrum. Br J Nutr. 2020 Mar 17:1-29. DOI:10.1017/S0007114520000951. PMID: 32180545.
Klinedinst BS, Pappas C, Le S, Yu S, Wang Q, Wang L, Allenspach-Jorn K, Mochel JP, Willette AA. Aging-Related Changes in Fluid Intelligence, Muscle and Adipose Mass, and Sex-Specific Immunologic Mediation: A longitudinal UKBiobank study. Brain Behav Immun. 2019 Sep 9. Pii: S0889-1591(19)30653-1. DOI: 10.1016/j.bbi.2019.09.008. PMID:31513875.
Schneider BKS, Boyer A, Ciccolini J, Wang K, Benzekry S, Mochel JP. Optimal Scheduling of Bevacizumab andPemetrexed/Cisplatin Dosing in Non-Small Cell Lung Cancer. CPT Pharmacometrics Syst Pharmacol. 2019 Apr 19.DOI: 10.1002/psp4.12415. PMID: 31004380.
