Department of Pathology
Anatomic Pathology, Associate Professor
Biography
Research Interests
- Transmissible spongiform encephalopathies (TSEs; prion diseases) using sheep scrapie as natural model system.
- Determinants of permissiveness: identification of determinants to explain the marked cell-to-cell and organism-to-organism variability regarding permissiveness to prions. Goal: increase the understanding of the cellular biology of prion diseases; develop more effective control measures and improved bioassays for prion infectivity.
- Inhibitors of prions: We have identified one monocationic, furan-containing small molecule that inhibits prion accumulation in two cell culture models. Future work involves structure-activity relationship studies by testing related compounds for anti-prion activity.
- Next-Generation Sequencing to determine the pathogenesis of diseases and to develop novel diagnostic tests for infectious diseases and neoplasia
- MinION sequencing: Real-time, portable sequencing
- Illumina sequencing: Deep sequencing for transcriptomics
- Other projects: Investigating the interaction of viruses and monocyte-derived cells, using organ culture to study virus-host interactions, and providing histopathology for a variety of other research projects.
Educational Background
- Diplomate, 2009, American College of Veterinary Pathologists
- PhD, 2008, Veterinary Science, Washington State University, Pullman, Wash.
- DVM, 2001, University of Georgia, Athens, Ga.
Teaching Experience
- 2018 - present: Associate Professor, Department of Pathology, University of Georgia, Athens, GA
- 2014–2018:: Assistant Professor, Department of Pathology, University of Georgia, Athens, GA
- 2010–2014: Assistant Professor, Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Wash.
- 2008–2010: Clinical Assistant Professor, Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Wash.
Selected Publications
- He Y, Taylor TL, Dimitrov KM, Butt SL, Stanton JB, Goraichuk IV, Fenton H, Poulson R, Zhang J, Brown CC, Ip HS, Isidoro-Ayza M, Afonso CL: Accepted. Whole-genome sequencing of genotype VI Newcastle disease viruses from formalin-fixed paraffin-embedded tissues from wild pigeons reveals continuous evolution and previously unrecognized genetic diversity in the U.S. Virology Journal.
- Dinkel KD, Schneider DA, Muñoz-Gutiérrez JF, McElliott VR, and Stanton JB. Correlation of cellular factors and differential scrapie prion permissiveness in ovine microglia. Virus Research 240:69–80, 2017. DOI: 10.1016/j.virusres.2017.07.016. PMID: 28754560.
- Stanton JB, Swanson BE, Orozco E, Muñoz-Gutiérrez JF, Evermann JF, and Ridpath, J. Immortalized ovine microglial cells are permissive to a diverse range of ruminant viruses. Veterinary Quarterly 37:52–56, 2017. DOI: 10.1080/01652176.2017.1297550. PMID: 28293985.
- Dinkel KD, Stanton JB, Boykin DW, Stephens CE, Madsen-Bouterse, SA, and Schneider DA. Anti-prion activity of DB772 and related monothiophene/furan-based analogs in a persistently infected ovine microglial culture system. Antimicrobial Agents and Chemotherapy. 60:5467–5482, 2016. DOI: 10.1128/AAC.00811-16. PMCID: PMC4997874.
- Muñoz-Gutiérrez JF, Pierlé SA, Schneider DA, Baszler TV, and Stanton JB. Transcriptomic determinants of scrapie susceptibility in cultured ovine microglia. PLoS One 11:e0147727, 2016. PMCID: PMC4726464.
- Additional Publications by Dr. Stanton may be found here.
