Department of Infectious Diseases, Office of the Dean
Dean, Georgia Athletic Association Distinguished Professor in Veterinary Medicine

Pathogenesis of bacterial diseases in animals and human beings


Dr. Lisa K. Nolan is the Georgia Athletics Association Distinguished Professor and Dean of the University of Georgia’s College of Veterinary Medicine. Prior to joining UGA, she served as professor and Dr. Stephen G. Juelsgaard Dean (2011-2017), associate dean of research and graduate studies (2009-2011), associate dean of academic and student affairs (2007-2009), and chair of the Department of Veterinary Microbiology and Preventive Medicine (2003-2008) at Iowa State University’s College of Veterinary Medicine. She was also Professor and Founding Director of the Great Plains Institute of Food Safety at North Dakota State University (1999-2003).

Nolan has received several honors over the course of her career, including being named a Fellow of the American Association for the Advancement of Science and the American Academy of Microbiology, an honorary diplomate of the American Veterinary Epidemiology Society, a Distinguished Educator Award from the Blue Key National Honor Society, and the Academic Alumnus of 2016 from the UGA College of Veterinary Medicine.

Her research focuses on bacterial diseases that impact animal health, human health and food safety. In particular her primary focus has been on the Escherichia coli that cause avian colibacillosis and human urinary tract infections and neonatal meningitis.

Nolan earned her BS from Valdosta State College and DVM, MS and PhD from UGA.

Research Interests

Her research focuses on bacterial diseases that impact animal health, human health and food safety.  In particular her primary focus has been on the Escherichia coli that cause avian colibacillosis and human urinary tract infections and neonatal meningitis.

Educational Background

  • BS, Valdosta State College
  • DVM, UGA
  • MS & PhD (Medical Microbiology), UGA

Selected Publications

  1. Rodriguez-Siek, K.E., Giddings, C.W., Fakhr, M., Doetkott, C., Johnson, T.J., and Nolan, L.K.  2005. Characterizing an APEC Pathotype.  Vet Res. 36: 1-16.
  2. Rodriguez-Siek, K.E., Giddings, C.W., Johnson, T.J., Fakhr, M., Doetkott, C., and Nolan, L.K.  2005.  Comparison of Escherichia coli Implicated in Human Urinary Tract Infection and Avian Colibacillosis. Microbiol. 151: 2097-2110.
  3. Johnson, T.J., Siek, K.E., Johnson, S.J., and Nolan, L.K.  2005.  DNA Sequence and Comparative Genomics of pAPEC-O2-R, an Avian Pathogenic Escherichia coli (APEC) Transmissible R Plasmid.  Antimicrob Agents Chemother. 49: 4681-4688.
  4. Johnson, T.J., Siek, K.E., Johnson, S., and Nolan, L.K.  2006.  Complete Sequence of a ColV Plasmid and Prevalence of Selected Plasmid-Encoded Virulence Genes among Avian Escherichia coli Strains.  J Bacteriol. 188: 745-758
  5. Skyberg, J.A., Johnson, T.J., Johnson, J.R., Clabots, C., Logue, C.M., and Nolan, L.K. 2006.  Acquisition of Avian Pathogenic Escherichia coli Plasmids by a Commensal E. coli Isolate Enhances Its Abilities to Kill Chick Embryos, Grow in Human Urine, and Colonize the Murine Kidney.  Infect Immun.  74: 6287-6292.
  6. Johnson, T.J., Kariyawasam, S., Wannemuehler, Y., Mangiamele, P., Johnson, S.J., Doetkott, C., Skyberg, J.A., Lynne, A.M., and Nolan, L.K.  2007.  Genome Sequence of Avian Pathogenic Escherichia coli Strain O1:K1:H7 Shares Strong Similarities with Human ExPEC Genomes.  J Bacteriol. 189: 3228-3236.  According to the Council of Canadian Academies, this paper is “one of the top 1% most highly cited papers in your field worldwide”.
  7. Johnson, T.J., Wannemuehler, Y., Johnson, S.J.,Stell, A.L., Doetkott, C., Johnson, J.R., Kim, K.S., Spanjaard, L., and Nolan, L.K.  2008.  Comparison of Extraintestinal Pathogenic Escherichia coli from Human and Avian Sources Reveals a Mixed Subset Representing Potential Zoonotic Pathogens.  Appl Environ Microbiol. 74: 7043-7050.
  8. Johnson, T.J., Wannemuehler, Y.M., Doetkott, C., Johnson, S.J., Rosenberger, S.C., and Nolan, L.K.  2008.  Identification of Minimal Predictors of Avian Pathogenic Escherichia coli (APEC) Virulence for Use as a Rapid Diagnostic Tool.  J Clin Microbiol. 46:3987-96.
  9. Johnson, T.J., Wannemuehler, Y., Doetkott, C., Johnson, S.J., White, D.G., and Nolan, L.K.  2009.  Examination of the Source and Extended Virulence Genotypes of Escherichia coli Contaminating Retail Poultry Meat.  Food Pathog Dis 6:657-667.
  10. Johnson, T.J. and Nolan, L.K.  2009.  Pathogenomics of the Virulence Plasmids of Escherichia coli.  Microbiol Mol Biol Rev.  73: 750-774.
  11. Li, G., Feng, Y., Kariyawasam, S., Tivendale, K.A., Wannemuehler, Y.M., Zhou, F., Logue, C.M., and Nolan, L.K.  2009.  AatA is a Novel Autotransporter and Virulence Factor of Avian Pathogenic Escherichia coli Infect Immun. 78: 898-906.
  12. Gaukler, S.M., Linz, G.M., Sherwood, J.S., Dyer, N.W., Bleier, W.J., Wannemuehler, Y.M., Nolan, L.K., and Logue, C.M.  2009.  Escherichia coli, Salmonella, Mycobacterium avium subsp., paratuberculosis in Wild European Starlings at a Kansas Cattle Feedlot.  Avian Dis.  53: 544-551.
  13. Johnson, T.J., Jordan, D., Kariyawasam, S., Stell, A.L., Bell, N.P., Wannemuehler, Y.M., Fernández-Alarcón, C., Li, G., Tivendale, K.A., Logue, C.M., and Nolan, L.K.  2010.  Sequence Analysis and Characterization of a Transferable Hybrid R/ColV Plasmid Encoding Multidrug Resistance and Enabling Zoonotic Potential for Extraintestinal Escherichia coli.  Infect Immun. 78: 1931–1942.
  14. Tivendale, K.A., Logue, C.M., Kariyawasam, S., Jordan, D., Hussein, A., Li, G., Wannemuehler, Y., and Nolan, L.K.  2010.  Avian Pathogenic Escherichia coli are Indistinguishable from Neonatal Meningitis E. coli and are Able to Cause Meningitis in 5-Day-Old Rats. Infect Immun. 78: 3412–3419.  [Selected for the Journal Highlights section of the September 2010 issue of ASM’s Microbe]
  15. Li, G., Tivendale, K.A., Liu, P., Feng, Y., Wannemuehler, Y., Cai, W., Mangiamele, P., Johnson, T.J., Constantinidou, C., Penn, C.W., and Nolan, L.K.  2011.  Transcriptome Analysis of Avian Pathogenic Escherichia coli O1 in Chicken Serum Reveals Adaptive Responses to Systemic Infection. Infect Immun. 79: 1951-1960.
  16. Johnson, T.J., Logue, C.M., Johnson, J.R., Kuskowski, M.A., Barnes, H.J., DebRoy, C., Wannemuehler, Y.M., Obata-Yasuoka, M., Spanjaard, L., and Nolan, L.K.  2011.  Associations between Multidrug Resistance, Plasmid Content and Virulence Potential among ExPEC and Commensal Escherichia coli from Humans and Poultry. Foodborne Path Dis. 9:37-46.
  17. Lynne, A.M., Kariyawasam, S., Wannemuehler, Y.M., Johnson, T.J., Johnson, S.J., Sinha, A.S., Lynne, D.K., Moon, H.W., Jordan, D.M., Logue, C.M., Foley, S.L., and Nolan, L.K.  2012.  Recombinant Iss as a Potential Vaccine for Avian Colibacillosis. Avian Dis. 56:192-9.
  18. Li, G., Cai, W., Hussein, A. , Wannemuehler, Y.M., Logue, C.M., and Nolan, L.K.1* 2012. Proteome Response of an Extraintestinal Pathogenic Escherichia coli Strain with Zoonotic Potential to Human and Chicken Sera.  J Proteomics 75: 4853-4862 (EPub ahead of print) *(Highlighted by NewsRx).
  19. Logue, C.M., Doetkott, C., Mangiamele, P., Wannemuehler, Y.M., Johnson, T.J., Tivendale, K.A., Li, G., Sherwood, J.S., and Nolan, L.K.  2012.  Logue, C.M., Doetkott, C., Mangiamele, P., Wannemuehler, Y.M., Johnson, T.J., Tivendale, K.A., Li, G., Sherwood, J.S., and Nolan, L.K.  2012.  Genotypic and Phenotypic Traits that Distinguish Neonatal Meningitis Escherichia coli from Fecal E. coli Isolates of Healthy Human Hosts.  Appl Environ Microbiol.  78: 5824-30.
  20. Nie, Q., Sandford, E.E., Zhang, X., Nolan, L.K., Lamont, S.J.  2012.  Deep Sequencing-Based Transcriptome Analysis of Chicken Spleen in Response to Avian Pathogenic Escherichia coli (APEC) Infection. PLoS ONE 7:e41645. Epub 2012 Jul 31
  21. Wentong Cai1, Yvonne Wannemuehler1, Subhashinie Kariyawasam2, Yaping Feng3, Catherine Logue1, Lisa K. Nolan1, Ganwu Li1*.  2012.  A Novel Two-Component Signaling System Facilitates Uropathogenic Escherichia coli to Exploit Abundant Host Metabolites.  PLoS PATH 9: e1003428
  22. Xu, H., Zhu, X., Hu, Y., Li, Z., Zhang, X., Nie, Q., Nolan, L.K., and Lamont, S.J.  2014.  DNA Methylome in the Spleen of Avian Pathogenic Escherichia coli-Challenged Broilers and Integration with mRNA Expression.  Science Reports 4: 4299-4308.
  23. Barbieri, N.L., Nicholson, B.A., Hussein, A., Cai, W., Wannemuehler, Y.M., Dell’Anna, G., Logue, C.M., Horn, F., Nolan, L.K., Li, G.  2014.  FNR Regulates the Expression of Important Virulence Factors Contributing to the Pathogenicity of Uropathogenic Escherichia coli.  Infect Immun 82:5086-98. doi: 10.1128/IAI.02315-14. Epub 2014 Sep 22
  24. Krishnan, S., Chang, A.C., Hodges, J., Couraud, P.-O., Romero, I.A., Weksler, B., Nolan, L.K., and Prasadarao, N.V.  2015.  Serotype O18 Avian Pathogenic and Neonatal Meningitis Escherichia coli Strains Employ Similar Pathogenic Strategies for the Onset of Meningitis.  Virulence DOI: 10.1080/21505594.2015.1091914
  25. Nolan, L.K., Li, G., and Logue, C.M.  2015.  Origin and Dissemination of Antimicrobial Resistance among Uropathogenic Escherichia coli Microbiol Spectrum 3: UTI-0007-2012. doi: 10.1128/microbiolspec. UTI-0007-2012.
  26. Sun, H., Liu, P., Nolan, L.K. and Lamont, S.J.  2015.  Novel Pathways Revealed in Bursa of Fabricius Transcriptome in Response to Extraintestinal Pathogenic Escherichia coli(ExPEC) Infection.  PLoS ONE 10(11): e0142570. doi: 10.1371/journal. pone.0142570
  27. Sun, H., Liu, P., Nolan, L. K., and Lamont, S. J.  2016. Thymus Transcriptome Reveals Novel Pathways in Response to Avian Pathogenic Escherichia coli Infection.  Poult Sci 95:2803-2814.
  28. Jia, X., Nie, Q., Zhang, X., Nolan, L.K., and Lamont, S.J.  2016.  Novel miRNA Involved in Host Response to Avian Pathogenic Escherichia coli Identified by Deep Sequencing and Integration Analysis.  Infect Immun Oct 17. pii: IAI.00688-16. [Epub ahead of print]
  29. Barbieri, N.L., Nielson, D.W., Wannemuehler, Y.M., Cavender, T., Hussein, A., Yan, S., Nolan, L.K., and Logue, C.M.  2017.  mcr-1 Identified in Avian Pathogenic Escherichia coli (APEC).  PLOS One 12(3): e0172997. doi:10.1371/journal.pone.0172997
  30. Barbieri, N.L., Vande Vorde, J.A., Baker, A.R., Horn, F., Li, G., Logue, C.M., and Nolan, L.K.  2017.  FNR Regulates the Expression of Important Virulence Factors Contributing to the Pathogenicity of Avian Pathogenic Escherichia coli.  Accepted by Front Microbiol.  5-20-17
  31. Li, G. et al.  2018.  O-specific Polysaccharide Confers Lysozyme Resistance to Extraintestinal Pathogenic Escherichia coli.  Virulence (accepted 1-12-18)
  32. Ma, J., An, C., Jiang, F., Yao, H., Logue, C.M., Nolan, L.K., and Li, G.  2018.  Extraintestinal Pathogenic Escherichia coli Increase Extracellular Polysaccharide Biosynthesis for Serum Resistance in Response to Bloodstream Signals.  Mol Microbiol (Accepted May 2018)
  33. Jø, S. L., Stegger, M., Kudirkiene, E., Lilje, B., Poulsen, L.L., Ronco, T., Pires Dos Santos, T., Kiil, K., Bisgaard, M., Pedersen, K., Nolan, L.K., Price, L.B., Olsen, R.H., Andersen, P.S., and Christensen, H.  2018.  Diversity and Population Overlap between Avian and Human Escherichia coli belonging to Sequence type ST95.  mSphere (Accepted July 2018)

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