Department of Physiology and Pharmacology
Graduate Coordinator for the Interdisciplinary Physiology and Pharmacology PhD, Professor

Reproductive Physiology | Toxicology


Research Interests

  • ​Molecular mechanism of embryo implantation
  • Endocrine disruptors and pregnancy

Educational Background

  • PhD (1999) University of California at Riverside
  • MPH (1993) Chinese Academy of Preventive Medicine, Beijing, China
  • ​MD (1990), Beijing Medical University (now Peking University), Beijing, China

Teaching Experience

  • ​Molecular Toxicology (VPHY 8960), Spring semester
  • Critical Reading of the Primary Scientific Literature (GRSC 8020), Fall semester

Selected Publications

  • ​Publications by Dr. Ye may be found at PubMed.
  • Li, R.#, Andersen, C.L. #, Hu, L., El Zowalaty, A.E., Wang, Z., Li, Y., Nagy, T., and Ye, X.* (2019) Dietary exposure to mycotoxin zearalenone (ZEA) during post-implantation adversely affects placental development in mice. Reprod Toxicol. doi:10.1016/j.reprotox.2019.01.010 “# equal authorship”.
  • Andersen, C.L., Liu, M., Wang, Z., Ye, X.*, and Xiao, S.* (2018) Chemotherapeutic agent doxorubicin alters uterine gene expression in response to estrogen in ovariectomized CD-1 adult mice. Biol Reprod. DOI: 10.1093/biolre/ioy259.
  • Andersen, C.L., Zhao, F., and Ye, X.* (2018) Effects of mycoestrogens on female reproduction. Reproductive and Developmental Medicine (RDM) 2:52-8. (DOI: 10.4103/2096-2924.232875)
  • El Zowalaty, A.E., Li, R., Chen, W., and Ye, X.* (2018) Seipin deficiency leads to increased ER stress and apoptosis in mammary gland alveolar epithelial cells during lactation. Biol Reprod. 98:570-578. doi:10.1093/biolre/iox169
  • El Zowalaty, A.E., and Ye, X. (2017) Seipin deficiency leads to defective parturition in mice. Biol Reprod; 97(3): 378-386. (PMID: 29088395) (DOI: 10.1093/biolre/iox088)
  • El Zowalaty, A.E., Li, R., Zheng, Y., Lydon, J.P., DeMayo, F.J., and Ye, X. (2017) Deletion of RhoA in progesterone receptor expressing cells leads to luteal insufficiency and infertility in female mice. Endocrinology. (PMID: 28498971) (DOI: 10.1210/en.2016-1796)
  • Xiao, S., Li, R., El Zowalaty, A.E., Diao, H., Zhao, F., Choi, Y., and Ye, X. (2017) Acidification of uterine epithelium during embryo implantation in mice. Biol Reprod; 96(1): 232-243. (PMID: 28395338) (DOI: 10.1095/biolreprod.116.144451)
  • Zhao, F., Zhou, J., Li, R., Dudley, E.A., and Ye, X. (2016) Novel function of LHFPL2 in female and male distal reproductive tract development. Sci Rep; 6: 23037; doi: 10.1038/srep23037 (PMID: 26964900) (PMCID: PMC4786858)
  • Diao, H., Li, R., El Zowalaty, A.E., Xiao, S., Zhao, F., Dudley, E.A., and Ye, X. (2015) Deletion of lysophosphatidic acid receptor 3 (Lpar3) disrupts fine local balance of progesterone and estrogen signaling in mouse uterus during implantation. Biol Reprod; 93(5): 123 (PMID: 26447143) (PMCID: PMC4712008)
  • Li, R., Diao, H., Zhao, F., Xiao, S., El Zowalaty, A.E., Dudley, E.A., Mattson, M.P., and Ye, X. (2015) Olfactomedin 1 deficiency leads to defective olfaction and impaired female fertility. Endocrinology; 156: 3344-3357. (PMID: 26107991) (PMCID: PMC4541623)
  • El Zowalaty, A.E., Baumann, C., Li, R., Chen, W., De La Fuente, R., and Ye, X. (2015) Seipin deficiency increases chromocenter fragmentation and disrupts acrosome formation leading to male infertility. Cell Death Dis; 6: e1817. (PMID: 26181198) (PMCID: PMC4650735)
  • Li, R., El Zowalaty, A.E., Chen, W., Dudley, E.A., and Ye, X. (2015) Segregated responses of mammary gland development and vaginal opening to prepubertal genistein exposure in Bscl2(-/-) female mice with lipodystrophy. Reprod Toxicol; 54: 76-83. (PMID: 25462787) (PMCID: 4420718)
  • Zhao, F., Zhou, J., El Zowalaty, A.E., Li R., Dudley, E.A., and Ye, X. (2014) Timing and recovery of postweaning exposure to diethylstilbestrol on early pregnancy in CD-1 mice. Reprod Toxicol; 49C: 48-54. (PMID: 25062584)
  • Zhao, F., Li, R., Xiao, S., Diao, H., El Zowalaty, A.E., and Ye, X. (2014) Multigenerational exposure to dietary zearalenone (ZEA), an estrogenic mycotoxin, affects puberty and reproduction in female mice. Reprod Toxicol; 47C: 81-8. (PMID: 24972337; PMCID: PMC4137769)
  • Xiao, S., Diao, H., Zhao, F., Li, R., He, N., and Ye, X. (2014) Differential gene expression profiling of mouse uterine luminal epithelium during periimplantation. Reprod Sci; 21(3): 351-62. (PMID: 23885106) (PMCID: PMC3936419)
  • Li, R., Zhao, F., Diao, H., Xiao, S., Ye, X. (2014) Postweaning dietary genistein exposure advances puberty without significantly affecting early pregnancy in C57BL/6J female mice. Reprod Toxicol; 44: 85-92. (PMID: 24365114) (PMCID: PMC4004695)
  • Diao, H., Xiao, S., Howerth, E.W., Zhao, F., Li, R., Ard, M.B., and Ye, X. (2013) Broad gap junction blocker carbenoxolone disrupts uterine preparation for embryo implantation in mice. Biol Reprod; 89(2): 31. (PMID: 23843229) (PMCID: PMC4076363)
  • Xiao, S., Diao, H., Zhao, F., Li, R., and Ye, X. (2013) Progesterone receptor-mediated regulation of N-acetylneuraminate pyruvate lyase (NPL) in mouse uterine luminal epithelium and nonessential role of NPL in uterine function. PLoS One; 8(5): e65607. (PMCID: PMC3669229)
  • Diao, H., Xiao, S., Li, R., Zhao, F., and Ye, X. (2013) Distinct spatiotemporal expression of serine proteases Prss23 and Prss35 in periimplantation mouse uterus and dispensable function of Prss35 in fertility. PLoS ONE; 8(2): e56757. (PMCID: PMC3579851)
  • Zhao, F., Li, R., Xiao, S., Diao, H., Viveiros, M.M., and Ye, X. (2013) Postweaning dietary exposure to zearalenone (ZEA), a mycotoxin, promotes puberty onset and disrupts early pregnancy events in female mice. Toxicol Sci, 132(2): 431-42. (PMCID: PMC3595522)
  • Ye, X., Diao, H., Chun, J. (2012) 11-deoxy prostaglandin F(2alpha), a thromboxane A2 receptor agonist, partially alleviates embryo crowding in Lpar3(-/-) females. Fertil Steril; 97: 757-63. (PMCID: PMC3084612)
  • Xiao, S., Diao, H., Smith, M.A., Song, X., and Ye, X. (2011) Preimplantation exposure to bisphenol A (BPA) affects embryo transport, preimplantation embryo development, and uterine receptivity in mice. Reprod Toxicol; 32: 434-41. (PMCID: PMC3225705)
  • Ye, X., Herr, D.R., Diao, H., Rivera, R., and Chun, J. (2011) Unique uterine localization and regulation may differentiate LPA3 from other lysophospholipid receptors for its role in embryo implantation. Fertil Steril; 95: 2107-13 e4. (PMCID: PMC3315158)
  • Diao, H., Paria, B.C., Xiao, S., Ye X. (2011) Temporal expression pattern of progesterone receptor in the uterine luminal epithelium suggests its requirement during early events of implantation. Fertil Steril; 95: 2087-93. (PMCID: PMC3080439)
  • Diao, H., Aplin, J.D., Xiao, S., Chun, J., Li, Z., Chen, S., Ye, X. (2011) Altered Spatiotemporal Expression of Collagen Types I, III, IV, and VI in Lpar3-Deficient Peri-Implantation Mouse Uterus. Biol Reprod; 84: 255-65. (PMCID: PMC3071265)
  • Diao, H., Xiao, S., Zhao, F., and Ye, X. (2010) Uterine luminal epithelium specific proline-rich acidic protein 1 (PRAP1) as a marker for successful embryo implantation. Fertil Steril; 94: 2808-2811 e2801. (PMID: 20674898)
  • Diao, H.L., Xiao, S., Cui, J., Chun, J., Xu, Y., and Ye, X. (2010) Progesterone receptor-mediated upregulation of transthyretin (TTR) in pre-implantation mouse uterus. Fertil Steril; 93: 2750-2753. (PMCID: PMC3646416)
  • Ye, X.#, Hama, K.#, Contos, J.J., Anliker, B., Inoue, A., Skinner, M.K., Suzuki, H., Amano, T., Kennedy, G., Arai, H., et al. (2005) LPA3-mediated lysophosphatidic acid signalling in embryo implantation and spacing. Nature; 435: 104-108. (Comment in: Nature. 2005 May 5; 435(7038): 34-5.) # equal authorship (PMID: 15875025)(PMCID: PMC1369590)

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