Current Projects and Grants

Mitochondrial Bioenergetics and Neurocognitive Behavior

Project Description: Exploring the role of mitochondrial bioenergetics on hippocampal & hypothalamic neurocognitive function in response to diet and brain injury.

Funding Sources: Alliance for Regenerative Rehabilitation Research & Training, University of Georgia Obesity Initiative

Project Collaborators: Dr. Emily Noble and Dr. Frank West

Related Publications:

Mitochondrial populations (green) within a hippocampal tissue specimen

Regenerative Rehabilitation and Musculoskeletal Injury

Project Description: Investigating regenerative rehabilitation approaches to improve the function and quality of the remaining muscle after traumatic injury. Projects explore the underlying molecular mechanisms of impaired tissue plasticity after traumatic injury as well as muscle-bone interactions

Funding Sources: Department of Defense, National Institutes of Health

Project CollaboratorsDr. Sarah Greising

Regenerative rehabilitation combines regenerative medicine approaches (e.g., a cellular scaffold in blue) with rehabilitation to maximize the tissue repair and plasticity. Ideally, regenerative rehabilitation will result in cellular response greater than regenerative medicine or rehabilitation approaches alone.

Mitochondrial Bioenergetics, Cell Physiology & Cell Manufacturing

Project Description: Determine the role of mitochondria structure and function on cellular physiology and in the context of cell manufacturing (e.g., MSCs)

Funding Sources: NSF CMaT

Project Collaborators: Dr. Luke Mortensen and Dr. Ross Marklein

Related Publications:

Mitochondrial networks within healthy (top) and injured (bottom) skeletal muscle fibers. This loss of network organization is associated with several pathological features within skeletal muscle included impair mitochondrial respiration. An overarching goal of our lab is to determine how mitochondrial morphology and function impact cellular physiology and stem cell biology

Past Projects and Grants

Molecular Mechanisms of Muscle Regeneration

Project Description: Investigates the role of hypoxia-inducible factors in satellite cell dynamics. Also, investigates mTOR-targeted therapies for muscular dystrophy.

Funding Source: National Institutes of Health (to H. Yin), Muscular Dystrophy Associate (to A. Beedle)

Project Collaborators: Dr. Aaron Beedle and Dr. Hang Yin

Related Publications:

The Role of Autophagy in Skeletal Muscle

Project Description: Investigating the extent to which autophagy is sufficient and necessary for skeletal muscle adaptation to exercise and regeneration following trauma

Funding Source:

Project Collaborators: Dr. Hang Yin and Dr. Luke Mortensen

Related Publications:

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