My research interests span the ecology, evolution, population dynamics, and molecular epidemiology of emerging infectious diseases. I am primarily interested in viral disease systems, such as influenza A virus, where transmission at individual (including between host species), population and global scales are difficult to observe or quantify.
My laboratory studies mechanisms of respiratory innate immunity supporting immune responses to pathogens or underlying pathogeneses of lung diseases. The first major project focuses on cystic fibrosis lung disease and studies host-pathogen interactions between neutrophils and respiratory pathogens, Pseudomonas aeruginosa, Staphylococcus aureus and Mycobacterium abscessus. The second main project investigates […]
Dr. Karls is a Senior Research Scientist in the Infectious Diseases Department at the University of Georgia. He received undergraduate degrees in Biochemistry and Bacteriology from the University of Wisconsin-Madison. He earned his doctorate in Bacteriology from UW-Madison applying biochemistry and molecular genetics to study transcriptional control of bacterial photosynthesis. […]
Frederick D. Quinn, Ph.D., is Athletic Association Professor of Infectious Diseases, Head of the Department of Infectious Diseases and Interim Director of the Center for Vaccines and Immunology in the College of Veterinary Medicine at the University of Georgia. Dr. Quinn oversaw several laboratory groups at the Centers for Disease […]
One component of my research program consists of identifying and characterizing surface antigens expressed by pathogenic bacteria including Burkholderia pseudomallei and Burkholderia mallei. Given their cellular location at the host-pathogen interface, surface antigens play key roles in bacterial virulence. We believe that studying their biological functions will shed light on […]